39 Diseases That Start With The Letter U

Have you ever wondered about diseases that start with the letter “U”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter U, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter U.


Diseases That Start With U

The followings are some known and lesser-known diseases that begin with the letter U (In alphabetical order):

1. Ulcer: An ulcer is an open sore that develops on the skin or mucous membranes, most commonly occurring in the stomach lining (gastric ulcer) or the first part of the small intestine (duodenal ulcer). It is often caused by an imbalance between stomach acid and the protective lining. Treatment includes medications to reduce stomach acid and antibiotics to address underlying infections.

2. Ulcerative Colitis: Ulcerative colitis is a chronic inflammatory bowel disease that affects the colon and rectum, causing inflammation and ulcers in the lining of the large intestine. Common symptoms include abdominal pain, diarrhea, and rectal bleeding. Treatment aims to control inflammation through medications, lifestyle changes, and in severe cases, surgery may be necessary.

3. Ulnar Collateral Ligament (UCL) Injury: The UCL is a ligament in the elbow that stabilizes the joint. UCL injuries are often seen in athletes, especially baseball pitchers. Treatment options range from conservative approaches such as rest and physical therapy to surgical repair in severe cases.

4. Ulnar Nerve Entrapment: Ulnar nerve entrapment, also known as cubital tunnel syndrome, occurs when the ulnar nerve becomes compressed or irritated at the elbow, leading to numbness and tingling in the ring and little fingers. Treatment includes splinting, anti-inflammatory medications, and sometimes surgery.

5. Ulnar Neuropathy: Ulnar neuropathy is a condition in which the ulnar nerve is damaged or compressed at various points along its course. Symptoms include weakness and tingling in the hand and fingers. Treatment involves addressing the underlying cause and managing symptoms.

6. Umbilical Cord Symptoms: Umbilical cord symptoms refer to any abnormal conditions affecting the umbilical cord during pregnancy, such as umbilical cord prolapse or nuchal cord. Immediate medical attention is crucial in such cases.

7. Umbilical Hernia: An umbilical hernia occurs when a portion of the intestine protrudes through the abdominal wall near the belly button. Surgery may be required for large or symptomatic hernias.

8. Uncombable Hair Syndrome: Uncombable hair syndrome is a rare genetic condition where the hair is extremely frizzy, dry, and cannot be combed flat. There is no cure for this condition, but hair care measures can help manage the appearance of the hair.

9. Underactive Thyroid: Underactive thyroid, or hypothyroidism, occurs when the thyroid gland does not produce enough thyroid hormones. It leads to fatigue, weight gain, and other symptoms. Hormone replacement therapy is used to manage hypothyroidism.

10. Undifferentiated Connective Tissue Disease (UCTD): UCTD is a condition characterized by symptoms and laboratory findings similar to connective tissue diseases like lupus, scleroderma, or rheumatoid arthritis. However, it does not meet the criteria for a specific disease. Treatment focuses on managing specific symptoms and preventing complications.

11. Unilateral Retinoblastoma: Retinoblastoma is a rare eye cancer that usually affects young children. Unilateral retinoblastoma means that only one eye is affected. Treatment options include surgery, chemotherapy, and radiation therapy.

12. Unipolar Depression: Unipolar depression, also known as major depressive disorder, is a mood disorder characterized by persistent sadness and loss of interest in activities. Psychotherapy and antidepressant medications are used for treatment.

13. Unstable Angina: Unstable angina is a type of chest pain that occurs when there is reduced blood flow to the heart. It is a medical emergency that requires immediate attention to prevent a heart attack.

14. Unverricht Lundborg Disease (ULD): ULD is a rare form of epilepsy characterized by progressive myoclonic seizures. Treatment focuses on managing seizures with antiepileptic medications and supportive care.

15. Upper Respiratory Tract Infection: An upper respiratory tract infection (URTI) is a common infection affecting the nose, sinuses, throat, or larynx. It includes conditions like the common cold and influenza. Rest, hydration, and symptomatic relief are usually sufficient for recovery.

16. Uremia: Uremia is a serious condition where waste products build up in the bloodstream due to kidney failure. Dialysis or kidney transplantation is needed for treatment.

17. Ureteral Cancer: Ureteral cancer is a rare form of cancer that affects the tubes connecting the kidneys to the bladder. Treatment includes surgery, chemotherapy, and radiation therapy.

18. Urethritis: Urethritis is inflammation of the urethra, often caused by infections. Antibiotics or antiviral medications are used to treat the underlying infection.

19. Urinary Incontinence: Urinary incontinence is the involuntary leakage of urine, and it can have various causes. Treatment options range from behavioral strategies to medications and surgery, depending on the underlying cause.

20. Urinary Retention: Urinary retention is the inability to empty the bladder completely. Treatment depends on the cause and may involve catheterization or medications.

21. Urinary Tract Infection: A urinary tract infection (UTI) is a bacterial infection affecting any part of the urinary system. It is commonly treated with antibiotics.

22. Urinary Tract Obstruction: Urinary tract obstruction occurs when the flow of urine is blocked, often due to kidney stones or an enlarged prostate. Treatment depends on the cause and severity of the obstruction.

23. Urination Pain: Urination pain can result from various conditions like UTIs, kidney stones, or interstitial cystitis. Treatment involves addressing the underlying cause and managing pain.

24. Urticaria: Urticaria, also known as hives, is a skin condition characterized by itchy, raised welts. It can be triggered by allergens or other factors. Antihistamines and avoiding triggers can help manage urticaria.

25. Urticaria (Hives): Urticaria is another term for hives, a skin condition characterized by itchy, raised welts. Antihistamines and avoiding triggers are used for treatment.

26. Usher Syndrome: Usher syndrome is a rare genetic disorder causing hearing and vision loss. There is no cure, but hearing aids, cochlear implants, and visual aids can help manage the symptoms.

27. Uterine Adnexal Tumors: Uterine adnexal tumors are growths that develop in the tissues near the uterus, such as the ovaries or fallopian tubes. Treatment depends on the type of tumor and may involve surgery or chemotherapy.

28. Uterine Bleeding: Uterine bleeding refers to abnormal bleeding from the uterus, which can have various causes. Treatment depends on the underlying condition.

29. Uterine Cancer: Uterine cancer, also known as endometrial cancer, develops in the lining of the uterus. Early symptoms include abnormal vaginal bleeding, pelvic pain, and weight loss. Treatment options include surgery, radiation therapy, and chemotherapy.

30. Uterine Fibroids: Uterine fibroids are non-cancerous growths that develop in the uterus. They can cause pelvic pain, heavy menstrual bleeding, and pressure on nearby organs. Treatment may involve medications, minimally invasive procedures, or surgery, depending on the size and symptoms of the fibroids.

31. Uterine Polyps: Uterine polyps are small, benign growths that develop in the lining of the uterus. They can cause abnormal bleeding and may be removed surgically if necessary.

32. Uterine Prolapse: Uterine prolapse occurs when the uterus slips down into the vaginal canal due to weakened pelvic floor muscles. Treatment options include pelvic floor exercises, pessaries, and in severe cases, surgery to repair the prolapse.

33. Uterine Sarcoma: Uterine sarcoma is a rare type of cancer that develops in the muscles or other tissues of the uterus. Treatment involves surgery, radiation therapy, and chemotherapy, depending on the stage and type of sarcoma.

34. Uveal Effusion Syndrome: Uveal effusion syndrome is a condition where fluid accumulates in the uvea, the middle layer of the eye, leading to visual disturbances and eye pain. Treatment aims to reduce intraocular pressure and manage fluid accumulation.

35. Uveal Lymphoid Infiltration: Uveal lymphoid infiltration is a rare condition characterized by the presence of lymphocytes in the uvea, the middle layer of the eye. Treatment may involve monitoring, steroids, or other immunosuppressive medications.

36. Uveal Melanoma: Uveal melanoma is a type of eye cancer that affects the uvea. Early detection and treatment, such as radiation therapy or surgery, are crucial for better outcomes.

37. Uveitic Glaucoma: Uveitic glaucoma is a form of secondary glaucoma that occurs due to inflammation in the eye (uveitis). Treatment involves managing the underlying inflammation and reducing intraocular pressure.

38. Uveitis: Uveitis is inflammation of the uvea, the middle layer of the eye. It can be caused by various factors, including infections, autoimmune disorders, and trauma. Treatment depends on the underlying cause and may involve corticosteroids, immunosuppressive medications, or antibiotics.

39. Uveoparotid Fever: Uveoparotid fever, also known as Heerfordt syndrome, is a rare manifestation of sarcoidosis, a condition that causes inflammation in various organs. Uveoparotid fever involves symptoms such as fever, enlargement of the salivary glands, and eye inflammation. Treatment focuses on managing sarcoidosis with medications like corticosteroids.


I hope you found this article “Diseases That Start With U” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter U.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With V
  • Diseases That Start With W
  • Diseases That Start With X
  • Diseases That Start With Y

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