107 Diseases That Start With The Letter S

Have you ever wondered about diseases that start with the letter “S”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter S, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter S.


Diseases That Start With S

The followings are some known and lesser-known diseases that begin with the letter S (In alphabetical order):

1. S. Pneumoniae: S. Pneumoniae, or Streptococcus Pneumoniae, is a bacterium responsible for causing various infections, including pneumonia, sinusitis, and meningitis. It can be particularly dangerous for young children, the elderly, and individuals with weakened immune systems. Vaccines are available to protect against certain strains of S. Pneumoniae.

2. Saethre-Chotzen Syndrome: Saethre-Chotzen Syndrome is a rare genetic disorder affecting craniofacial development. It is characterized by abnormalities in the shape of the skull, facial features, and fingers. Early diagnosis and appropriate medical management can help individuals with this syndrome lead fulfilling lives.

3. Salivary Gland Cancer: Salivary gland cancer is a type of malignancy that develops in the salivary glands responsible for producing saliva. Symptoms may include swelling, pain, or difficulty in moving the jaw. Treatment options may include surgery, radiation therapy, or chemotherapy.

4. Salmonella Infection: Salmonella infection is a foodborne illness caused by the Salmonella bacteria. Contaminated food or water is a common source of transmission. Symptoms include diarrhea, fever, and abdominal cramps. Hygiene and safe food handling practices can prevent infection.

5. Salmonellosis: Salmonellosis is another term for a Salmonella infection. It refers to the group of diseases caused by Salmonella bacteria and often leads to gastrointestinal issues.

6. Sandfly-borne Diseases: Sandfly-borne diseases are a group of illnesses transmitted by infected sandflies. One well-known example is Leishmaniasis, which affects the skin, mucous membranes, and internal organs.

7. Sarcoidosis: Sarcoidosis is an inflammatory condition that can affect multiple organs, particularly the lungs and lymph nodes. The cause of sarcoidosis remains unclear, and treatment aims to manage symptoms and prevent organ damage.

8. Scabies: Scabies is a contagious skin condition caused by the Sarcoptes scabiei mite. It leads to intense itching and a characteristic rash. Prompt treatment with scabicidal medications is necessary to eradicate the mites and prevent further transmission.

9. Scabies-Itch Mite Rash: Scabies-itch mite rash is the skin reaction caused by scabies mite infestation. It appears as small red bumps, blisters, or burrows and can be extremely itchy.

10. Scarlet Fever: Scarlet fever is a bacterial infection caused by Streptococcus pyogenes. It primarily affects children and presents with a distinctive rash, fever, and sore throat. Prompt treatment with antibiotics is essential to prevent complications.

11. Schistosomiasis: Schistosomiasis, also known as bilharzia, is a parasitic infection transmitted through freshwater snails. It affects the urinary and intestinal systems, leading to various symptoms. Preventive measures include avoiding contaminated water sources.

12. Schizophrenia: Schizophrenia is a severe mental disorder characterized by disturbances in thinking, emotions, and behavior. It requires long-term treatment, including medication and therapy.

13. Schmallenberg Virus: The Schmallenberg virus is an insect-borne virus that primarily affects cattle, sheep, and goats. It can cause congenital malformations in offspring.

14. Sciatica: Sciatica refers to pain that radiates along the sciatic nerve, often due to compression or irritation of the nerve roots in the lower back. Physical therapy and pain management techniques can provide relief.

15. Scleroderma: Scleroderma is a chronic autoimmune disease that causes hardening and tightening of the skin and connective tissues. It can also affect internal organs, making early diagnosis crucial for effective management.

16. Scoliosis: Scoliosis is a curvature of the spine that can develop during childhood or adolescence. It may require observation, bracing, or, in severe cases, surgery.

17. Scorpion Sting: Scorpion stings can cause pain, swelling, and redness at the sting site. In severe cases, they may lead to serious health issues, especially for children or those with allergies.

18. Scrape: A scrape, also known as an abrasion, occurs when the skin is rubbed or scraped off, often due to friction or falls. Proper wound care can prevent infections.

19. Seasonal Flu: Seasonal flu, also known as influenza, is a viral infection that affects the respiratory system. Annual vaccination is recommended to protect against seasonal flu strains.

20. Seasonal Influenza: Seasonal influenza refers to the flu virus infections that occur during specific times of the year. It is crucial to get vaccinated to prevent its spread.

21. Seizure: A seizure is a sudden and abnormal electrical activity in the brain, resulting in various symptoms, including convulsions. Medical attention is essential for individuals experiencing seizures.

22. Sepsis: Sepsis is a severe and potentially life-threatening condition caused by the body’s overwhelming response to infection. Early recognition and prompt treatment are vital for survival.

23. Septic Shock: Septic shock is a life-threatening condition that occurs when sepsis leads to dangerously low blood pressure and organ dysfunction. Immediate medical intervention is crucial.

24. Septicemia: Septicemia is a bloodstream infection often caused by bacteria. Early detection and appropriate antibiotics are essential to prevent complications.

25. Septoplasty: Septoplasty is a surgical procedure performed to correct a deviated septum, which can obstruct the nasal passages and cause breathing difficulties.

26. Serotonin Syndrome: Serotonin syndrome is a potentially dangerous condition caused by an excess of serotonin in the body. It usually results from the interaction of multiple medications affecting serotonin levels.

27. Severe Acute Respiratory Syndrome (SARS): SARS is a viral respiratory illness caused by the SARS-CoV virus. It was a significant outbreak in the early 2000s but has since been controlled.

28. Sexually Transmitted Infections: Sexually Transmitted Infections (STIs) are infections transmitted through sexual contact. Common examples include chlamydia, gonorrhea, syphilis, and HIV.

29. Shigellosis: Shigellosis is a bacterial infection caused by the Shigella bacteria, leading to diarrhea, fever, and abdominal pain. Proper hygiene and handwashing can prevent its spread.

30. Shingles: Shingles, also known as herpes zoster, is a viral infection causing a painful rash. Vaccination is available to prevent shingles in older adults.

31. Short Bowel Syndrome: Short Bowel Syndrome occurs when a significant portion of the small intestine is surgically removed or malfunctioning, leading to nutrient absorption difficulties. It may require dietary modifications and medical management.

32. Shortness of Breath: Shortness of breath is a symptom commonly associated with various respiratory and cardiac conditions. Identifying the underlying cause is crucial for effective treatment.

33. Shoulder Impingement: Shoulder impingement is a condition where the tendons in the shoulder become compressed, leading to pain and limited movement. Physical therapy and rest are often recommended.

34. Shwachman-Diamond Syndrome: Shwachman-Diamond Syndrome is a rare genetic disorder affecting multiple organs, including the bone marrow and pancreas. Early diagnosis and specialized care are necessary.

35. Sialadenitis: Sialadenitis is the inflammation of a salivary gland, typically caused by a bacterial infection or blockage. Warm compresses and antibiotics may be prescribed.

36. Sialolithiasis: Sialolithiasis refers to the formation of salivary gland stones, which can block the flow of saliva. Treatment may involve removal of the stone or conservative management.

37. Sickle Cell Anemia: Sickle Cell Anemia is a genetic blood disorder characterized by abnormal red blood cells. It can cause anemia and other complications, requiring regular medical care.

38. Sickle Cell Disease: Sickle Cell Disease encompasses a group of inherited blood disorders, including sickle cell anemia, affecting the shape and function of red blood cells.

39. Sindbis Fever: Sindbis Fever is a mosquito-borne viral infection, typically causing mild symptoms, such as fever and joint pain.

40. Sinus Pain: Sinus pain is usually associated with sinusitis, an inflammation of the sinuses. Treatments may include decongestants, nasal irrigation, and antibiotics if the cause is bacterial.

41. Sinus Tachycardia: Sinus tachycardia is a condition where the heart beats faster than normal due to various factors such as fever, stress, or exercise.

42. Sinusitis: Sinusitis is an inflammation of the sinuses, often caused by viral or bacterial infections. It leads to symptoms like facial pain, nasal congestion, and headaches.

43. Sjögren’s Syndrome: Sjögren’s Syndrome is an autoimmune disorder that primarily affects the salivary and tear glands, leading to dry mouth and eyes.

44. Skin Cancer: Skin cancer refers to the abnormal growth of skin cells, often due to exposure to ultraviolet (UV) radiation from the sun. Regular skin checks and sun protection are essential for prevention.

45. Skin Foreign Object: A skin foreign object is any foreign material that becomes embedded in the skin, causing irritation or infection. Proper wound cleaning is necessary for removal.

46. Skin Injury: A skin injury refers to damage to the skin, which can range from minor cuts to more severe wounds. Proper wound care is crucial for healing and preventing infections.

47. Skin Lump: A skin lump can be a benign growth or a more serious condition. Consulting a healthcare professional for evaluation is recommended.

48. Skin or Soft Tissue Infection: Skin and soft tissue infections can result from bacteria entering the body through cuts or wounds. Prompt treatment with antibiotics is vital to prevent complications.

49. Skin Rash: A skin rash is a common skin condition characterized by redness, itching, and inflammation. Identifying the underlying cause is essential for appropriate treatment.

50. Slapped Cheek Syndrome: Slapped Cheek Syndrome, or Fifth Disease, is a viral infection common in children. It presents with a distinctive rash on the cheeks and body.

51. Sleep Apnea: Sleep apnea is a sleep disorder characterized by interrupted breathing during sleep. Continuous Positive Airway Pressure (CPAP) machines are commonly used for treatment.

52. Sleep Disorders: Sleep disorders encompass various conditions affecting sleep patterns and quality. Proper sleep hygiene and medical interventions can improve sleep.

53. Slipped Capital Femoral Epiphysis (SCFE): SCFE is a hip disorder typically affecting adolescents, where the growth plate of the thighbone slips from its normal position. Surgery is often required for correction.

54. Sliver or Splinter: A sliver or splinter refers to a small, sharp object embedded in the skin. It requires careful removal to prevent infection.

55. Small Cell Lung Cancer: Small Cell Lung Cancer is a type of lung cancer that tends to grow and spread quickly. Early diagnosis and appropriate treatment are crucial for better outcomes.

56. Smallpox: Smallpox is a highly contagious and deadly viral disease, although it has been eradicated through global vaccination efforts.

57. Smoking Cessation: Smoking cessation refers to the process of quitting smoking to improve overall health and reduce the risk of various diseases.

58. Soft Tissue Sarcomas: Soft tissue sarcomas are rare cancers that develop in the soft tissues of the body. Treatment options may include surgery, radiation, and chemotherapy.

59. Sore Throat: A sore throat is a common symptom of various viral or bacterial infections. Rest, hydration, and throat lozenges can provide relief.

60. Spasticity: Spasticity is a condition where certain muscles become stiff and difficult to control due to neurological issues. Physical therapy and medications can help manage spasticity.

61. Spider Bite: Spider bites can cause redness, swelling, and itching at the site of the bite. While most spider bites are harmless, some can be venomous and require medical attention.

62. Spina Bifida: Spina bifida is a congenital condition where the spine and spinal cord do not develop properly. Treatment depends on the severity and may involve surgery and supportive care.

63. Spinal Cord Injury: Spinal cord injuries result from damage to the spinal cord, often leading to paralysis or loss of sensation below the injury site. Rehabilitation plays a crucial role in improving functionality and quality of life.

64. Spinal Muscular Atrophy (SMA): SMA is a genetic disorder affecting the nerve cells responsible for muscle control. There are different types of SMA, and supportive therapies can help manage symptoms.

65. Spinal Stenosis: Spinal stenosis refers to the narrowing of the spaces within the spine, putting pressure on the spinal cord and nerves. Treatment may involve physical therapy, medications, or surgery.

66. Spondylolisthesis: Spondylolisthesis is a condition where one vertebra slips forward over the one below it. It can cause back pain and nerve compression, requiring medical evaluation and treatment.

67. Spondylosis: Spondylosis, also known as spinal osteoarthritis, is a degenerative condition that affects the spine’s discs and joints, leading to pain and stiffness.

68. Sports Injuries: Sports injuries can vary from minor sprains and strains to more severe fractures and dislocations. Proper training, warm-up, and safety equipment can help prevent injuries.

69. Staphylococcal Infections: Staphylococcal infections are caused by Staphylococcus bacteria and can lead to a wide range of illnesses, from minor skin infections to severe bloodstream infections.

70. STD Prophylaxis: STD prophylaxis refers to the use of medications to prevent the transmission of sexually transmitted infections, particularly after potential exposure.

71. Stevens-Johnson Syndrome: Stevens-Johnson Syndrome is a severe and rare skin reaction, often triggered by certain medications. It requires immediate medical attention as it can be life-threatening.

72. STI Exposure: STI exposure refers to the situation when an individual has come into contact with someone infected with a sexually transmitted infection.

73. Stickler Syndrome: Stickler Syndrome is a genetic disorder affecting collagen production, leading to various connective tissue problems, particularly in the eyes, ears, and joints.

74. Stillbirth: Stillbirth refers to the loss of a baby before birth, typically after the 20th week of pregnancy. Grieving parents may need emotional support and counseling.

75. Still’s Disease: Still’s Disease, also known as Systemic Juvenile Idiopathic Arthritis, is a form of juvenile arthritis with systemic inflammation. Early diagnosis and treatment can help manage symptoms.

76. Stomach Cancer: Stomach cancer, also called gastric cancer, affects the lining of the stomach. Early detection is essential for successful treatment.

77. Stomach Ulcer: A stomach ulcer is a sore that develops on the lining of the stomach, often caused by the H. pylori bacteria or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).

78. Stools – Blood In: Blood in stools can be a sign of various gastrointestinal conditions, and immediate medical attention is necessary for evaluation.

79. Stools – Unusual Color: Unusual stool color can indicate issues with digestion, diet, or certain medical conditions, requiring further investigation if persistent.

80. Strabismus: Strabismus, also known as crossed eyes, is a vision condition where the eyes do not align properly. Early intervention can prevent vision problems.

81. Strep Throat Exposure: Strep throat exposure refers to being in contact with someone infected with Streptococcus bacteria, which can cause a sore throat.

82. Strep Throat Infection: Strep throat is a bacterial infection causing a sore and inflamed throat. Antibiotics are typically prescribed for treatment.

83. Streptococcus A (strep A): Streptococcus A, or strep A, is a type of bacteria that can cause various infections, including strep throat and skin infections.

84. Streptococcus Pneumoniae: Streptococcus pneumoniae is a bacterium responsible for pneumonia, sinusitis, and other infections. Vaccination is available to prevent certain strains.

85. Stress: Stress is the body’s response to challenges, and chronic stress can have negative effects on physical and mental health. Managing stress through relaxation techniques and lifestyle changes is essential.

86. Stroke: A stroke occurs when there is a sudden disruption of blood flow to the brain, leading to brain cell damage. Recognizing the signs and seeking immediate medical attention is crucial for minimizing brain damage.

87. Sturge-Weber Syndrome: Sturge-Weber Syndrome is a rare neurological disorder characterized by abnormal blood vessels in the brain and skin. Early intervention and supportive care are essential.

88. Sty: A sty is a red, painful lump that develops near the edge of the eyelid due to a blocked oil gland. Warm compresses can help with its resolution.

89. Subarachnoid Hemorrhage: A subarachnoid hemorrhage is a type of stroke caused by bleeding into the space surrounding the brain. It requires urgent medical attention.

90. Substance Use Disorder: Substance use disorder refers to the misuse or dependence on drugs or alcohol, requiring intervention and treatment for recovery.

91. Sudden Cardiac Arrest: Sudden cardiac arrest occurs when the heart suddenly stops beating, leading to loss of consciousness and necessitating immediate cardiopulmonary resuscitation (CPR) and defibrillation.

92. Sudden Infant Death Syndrome (SIDS): SIDS is the unexpected and unexplained death of an otherwise healthy infant during sleep. Safe sleep practices can reduce the risk.

93. Sudden Sensorineural Hearing Loss (SSHL): SSHL is a rapid hearing loss that occurs due to damage to the inner ear structures. Prompt medical attention may improve outcomes.

94. Sunburn: Sunburn is the skin’s response to excessive UV radiation, leading to redness, pain, and peeling. Sun protection is vital to prevent sunburn and reduce the risk of skin cancer.

95. Supraventricular Arrhythmia: Supraventricular arrhythmia is an abnormal heart rhythm originating above the ventricles. It may cause palpitations and dizziness.

96. Supraventricular Tachycardia (SVT): SVT is a rapid heart rate originating above the ventricles, often requiring medical intervention to restore normal rhythm.

97. Swallowed Foreign Object: Swallowed foreign objects can become lodged in the throat or digestive tract, requiring medical attention for removal.

98. Swallowed Harmless Substance: Swallowing harmless substances, like food, is a normal part of eating and digestion.

99. Swimmer’s Ear: Swimmer’s ear, also known as otitis externa, is an infection of the outer ear canal, often caused by water remaining in the ear after swimming. Proper drying and ear drops can help prevent and treat the condition.

100. Swine Flu (H1N1): Swine flu, caused by the H1N1 influenza virus, is a respiratory infection that can spread from pigs to humans and between people. Vaccination is available to protect against the virus.

101. Swollen Glands: Swollen glands, also known as swollen lymph nodes, are a common sign of infection or inflammation in the body. Identifying the underlying cause is crucial for appropriate treatment.

102. Swollen Lymph Nodes: Swollen lymph nodes are part of the body’s immune response to infections and can occur in various regions, such as the neck, armpits, and groin.

103. Symbrachydactyly: Symbrachydactyly is a congenital condition where a child is born with missing or underdeveloped fingers or hands.

104. Syndactyly: Syndactyly is a congenital condition characterized by fused fingers or toes. Surgical correction may be considered for functional and cosmetic reasons.

105. Syphilis: Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. Early detection and treatment are essential to prevent complications.

106. Syringomyelia: Syringomyelia is a disorder where a cyst or cavity forms within the spinal cord, leading to various neurological symptoms. Treatment may involve surgery.

107. Systemic Lupus Erythematosus (SLE): SLE is a chronic autoimmune disease that can affect various organs, joints, and tissues in the body. It requires ongoing medical management and may involve medications to control the immune response.


I hope you found this article “Diseases That Start With S” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter S.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With T
  • Diseases That Start With U
  • Diseases That Start With V
  • Diseases That Start With W

Munshur A

Munshur A is the man behind learningandliving.net. An automobile engineer and passionate blogger, who loves to learn and share new things with his reader.

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