64 Diseases That Start With The Letter R

Have you ever wondered about diseases that start with the letter “R”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter R, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter R.


Diseases That Start With R

The followings are some known and lesser-known diseases that begin with the letter R (In alphabetical order):

1. Rabies: Rabies is a viral disease transmitted through the bite of infected animals. It affects the central nervous system, leading to severe neurological symptoms and, if left untreated, it is almost always fatal. Immediate medical attention, including post-exposure prophylaxis, is essential for individuals bitten by potentially rabid animals.

2. Radiation Sickness: Radiation sickness occurs when the body is exposed to high levels of ionizing radiation, typically from nuclear accidents or medical radiation therapy. Symptoms can include nausea, vomiting, hair loss, and a weakened immune system. Treatment aims to manage symptoms and support the body’s recovery.

3. Ramsay Hunt Syndrome: Ramsay Hunt syndrome is a viral infection caused by the varicella-zoster virus (the same virus that causes chickenpox and shingles). It affects the facial nerve, leading to facial paralysis, ear pain, and a characteristic rash. Antiviral medications can help manage the infection and reduce complications.

4. Rare Tumors: Rare tumors refer to a diverse group of uncommon cancers that occur infrequently in the population. Treatment and prognosis vary depending on the type and stage of the tumor. Clinical trials and specialized treatments may be available for certain rare tumors.

5. Rash: A rash is a widespread skin eruption that can result from various causes, such as allergies, infections, or autoimmune conditions. Proper diagnosis and management depend on identifying the underlying cause of the rash.

6. Raynaud Disease: Raynaud disease is a condition where blood vessels in the fingers and toes excessively constrict in response to cold or stress, leading to reduced blood flow and color changes in the skin. Avoiding triggers and keeping extremities warm are essential for symptom relief.

7. Raynaud’s Phenomenon: Raynaud’s phenomenon is similar to Raynaud disease, but it is secondary to an underlying condition, such as autoimmune disorders or connective tissue diseases. Treating the underlying condition can help manage Raynaud’s phenomenon.

8. Reactive Arthritis: Reactive arthritis is joint inflammation that occurs as a reaction to an infection in another part of the body, typically the gastrointestinal or genitourinary systems. It can lead to painful, swollen joints and other symptoms. Antibiotics or other treatments are used to manage the underlying infection and alleviate arthritis symptoms.

9. Rectal Abscess: A rectal abscess is a painful, localized collection of pus near the rectum. It often requires drainage and antibiotic treatment to promote healing.

10. Rectal Bleeding: Rectal bleeding can result from various causes, including hemorrhoids, anal fissures, or more serious conditions like colorectal cancer. Seeking prompt medical evaluation is essential to identify the cause and begin appropriate treatment.

11. Rectal Cancer: Rectal cancer is cancer that develops in the tissues of the rectum. Early detection through screening and proper treatment, such as surgery, radiation, and chemotherapy, are critical for favorable outcomes.

12. Rectal Pain: Rectal pain can arise from various conditions, including anal fissures, hemorrhoids, or proctitis. Treatment depends on the underlying cause and may include medications or lifestyle modifications.

13. Red Man Syndrome: Red Man syndrome is an adverse reaction to certain antibiotics, causing redness and flushing of the upper body and face. Slowing down the infusion rate of the antibiotic can help prevent this reaction.

14. Reflux (Spitting Up): Reflux, also known as spitting up, is common in infants, where stomach contents flow back into the esophagus. Most cases resolve on their own without treatment.

15. Refractive Errors: Refractive errors, including myopia (nearsightedness), hyperopia (farsightedness), and astigmatism, result from abnormalities in the eye’s focusing ability. Corrective lenses or refractive surgery can help improve vision.

16. Reiter’s Syndrome: Reiter’s syndrome is a rare condition characterized by joint inflammation, eye inflammation (conjunctivitis/uveitis), and urinary tract symptoms. Treatment aims to manage symptoms and address the underlying infection, often triggered by bacteria.

17. Relapsed Acute Lymphoblastic Leukemia: Relapsed acute lymphoblastic leukemia (ALL) refers to a recurrence of leukemia after a period of remission. It requires intensive treatment, such as chemotherapy and stem cell transplantation, to achieve remission again.

18. Relapsing Fever: Relapsing fever is a bacterial infection transmitted by ticks or lice, causing recurrent episodes of fever and flu-like symptoms. Antibiotics are used to treat the infection.

19. Relapsing Polychondritis: Relapsing polychondritis is an autoimmune disorder that leads to inflammation of cartilage throughout the body. Treatment aims to suppress the immune system to reduce inflammation.

20. Relapsing Remitting Multiple Sclerosis (RRMS): Relapsing-remitting multiple sclerosis (RRMS) is the most common form of multiple sclerosis (MS), characterized by periods of flare-ups (relapses) followed by periods of remission. Disease-modifying therapies help reduce relapses and slow disease progression.

21. Renal Agenesis: Renal agenesis is a congenital condition where one or both kidneys fail to develop during fetal development. It can lead to complications and requires medical management and monitoring.

22. Renal Artery Stenosis: Renal artery stenosis is the narrowing of the arteries supplying blood to the kidneys, leading to reduced blood flow and potential hypertension. Treatment may involve medication or surgical interventions.

23. Renal Calculi (Kidney Stones): Renal calculi, commonly known as kidney stones, are hard mineral and salt deposits that form in the kidneys or urinary tract. Treatment options include pain management, hydration, and in some cases, procedures to remove or break up the stones.

24. Renal Cancer: Renal cancer, or kidney cancer, can develop in the tissues of the kidneys. Treatment options depend on the stage and type of cancer and may include surgery, radiation, or immunotherapy.

25. Renal Cell Carcinoma: Renal cell carcinoma is the most common type of kidney cancer, originating in the cells lining the small tubes within the kidneys. Treatment strategies involve surgery, targeted therapy, and immunotherapy.

26. Renal Failure: Renal failure refers to the loss of kidney function, leading to the accumulation of waste and fluids in the body. Treatment involves addressing the underlying cause and managing symptoms, which may include dialysis or kidney transplantation.

27. Renal Hypertension: Renal hypertension is high blood pressure caused by kidney-related factors, such as narrowed arteries or hormone imbalances. Managing blood pressure through medication and lifestyle changes is essential to prevent complications.

28. Renal Osteodystrophy: Renal osteodystrophy is a bone disorder that occurs in people with chronic kidney disease. It is characterized by imbalances in minerals and hormones that affect bone health. Treatment may involve medications and dietary modifications.

29. Renal Tubular Acidosis: Renal tubular acidosis is a condition where the kidneys are unable to properly maintain the body’s acid-base balance. Treatment aims to correct acidosis and manage any underlying kidney issues.

30. Reperfusion Injury: Reperfusion injury occurs when blood flow is restored to tissues after a period of reduced blood supply, such as during a heart attack or stroke. The sudden influx of oxygen can cause damage, and treatment focuses on minimizing the impact and promoting healing.

31. Respiratory Alkalosis: Respiratory alkalosis is a condition characterized by increased pH levels in the blood due to hyperventilation. Addressing the underlying cause of rapid breathing is essential for restoring acid-base balance.

32. Respiratory Distress Syndrome: Respiratory distress syndrome, commonly seen in premature infants, is a condition where the lungs are not fully developed, leading to difficulty breathing. Supportive care, including mechanical ventilation and surfactant administration, is crucial for managing this condition.

33. Respiratory Syncytial Virus (RSV) Infection: RSV infection is a common respiratory illness that can cause severe symptoms, especially in young children and older adults. Treatment is usually supportive, focusing on relieving symptoms and preventing complications.

34. Restless Legs Syndrome: Restless legs syndrome is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. Lifestyle changes and medications can help manage symptoms.

35. Retinal Detachment: Retinal detachment occurs when the light-sensitive layer of the eye (the retina) separates from its underlying tissue. Immediate surgery is necessary to reattach the retina and prevent vision loss.

36. Retinal Vein Occlusion: Retinal vein occlusion is a blockage in the veins that drain blood from the retina, leading to vision loss. Management involves identifying and addressing underlying risk factors.

37. Retinitis Pigmentosa: Retinitis pigmentosa is a group of inherited eye disorders that cause progressive vision loss due to degeneration of the retina’s light-sensitive cells. There is currently no cure, but treatment can help manage symptoms.

38. Retinoblastoma: Retinoblastoma is a rare childhood cancer that develops in the retina. Early detection and prompt treatment, such as surgery and chemotherapy, are essential for preserving vision and saving lives.

39. Retroperitoneal Fibrosis: Retroperitoneal fibrosis is a condition where abnormal tissue growth occurs in the retroperitoneum, the space behind the abdominal cavity. Treatment typically involves medications to reduce inflammation and open blocked structures.

40. Rett Syndrome: Rett syndrome is a rare genetic disorder that affects brain development, leading to severe cognitive and physical disabilities, typically seen in girls. Supportive care and early interventions can improve the quality of life for affected individuals.

41. Reversible Cerebral Vasoconstriction Syndrome (RCVS): RCVS is a rare condition characterized by sudden and severe headaches caused by constriction of brain blood vessels. Treatment focuses on managing symptoms and identifying and addressing triggers.

42. Reversible Posterior Leukoencephalopathy Syndrome (RPLS): RPLS is a neurological disorder characterized by reversible brain lesions and associated symptoms like headaches and seizures. Identifying and treating underlying causes is vital for recovery.

43. Reye’s Syndrome: Reye’s syndrome is a rare but serious condition that primarily affects children recovering from a viral infection, leading to liver and brain swelling. Avoiding the use of aspirin in children recovering from viral infections is essential for prevention.

44. Rhabdomyosarcoma: Rhabdomyosarcoma is a type of soft tissue cancer that develops from skeletal muscle cells. Treatment often involves a combination of surgery, chemotherapy, and radiation therapy.

45. Rheumatic Heart Disease: Rheumatic heart disease is a complication of untreated streptococcal throat infection that leads to damage to heart valves. Prevention through prompt treatment of strep throat is crucial.

46. Rheumatoid Arthritis: Rheumatoid arthritis is an autoimmune disorder characterized by joint inflammation, pain, and stiffness. Early diagnosis and appropriate treatment, including medications and lifestyle changes, are vital for managing the condition.

47. Rhinitis: Rhinitis is inflammation of the nasal passages, leading to symptoms like sneezing, nasal congestion, and runny nose. Treatment may involve allergen avoidance and medications.

48. Rhinoplasty: Rhinoplasty is a surgical procedure to reshape the nose for medical or cosmetic reasons. It can improve breathing and correct structural issues.

49. Rhinovirus Infection: Rhinovirus is a common cause of the common cold, leading to respiratory symptoms like cough and runny nose. Supportive care is usually sufficient for managing symptoms.

50. Rhizomelic Chondro Dysplasia Punctata (RCDP): RCDP is a rare genetic disorder that affects bone and cartilage development. Supportive care and symptom management can help improve the quality of life for affected individuals.

51. Rickets: Rickets is a condition where bones become weak and soft due to vitamin D deficiency. Treatment involves vitamin D supplementation and addressing underlying causes.

52. Rickettsiosis: Rickettsiosis is a group of bacterial infections transmitted through tick or mite bites. Antibiotics are used to treat these infections.

53. Rift Valley Fever: Rift Valley fever is a viral zoonotic disease transmitted to humans from animals. Preventive measures and supportive care are essential for managing the illness.

54. Ringworm: Ringworm is a fungal skin infection that can affect various parts of the body. Antifungal medications are typically used to treat the infection.

55. Robin Sequence: Robin sequence is a congenital condition characterized by a small lower jaw (micrognathia) and a tongue that falls back into the throat, causing breathing difficulties. Treatment may include positioning and, in some cases, surgery.

56. Rocky Mountain Spotted Fever: Rocky Mountain spotted fever is a tick-borne infection that can lead to severe symptoms and complications if not treated promptly with antibiotics.

57. Rosacea: Rosacea is a chronic skin condition that causes redness, flushing, and visible blood vessels on the face. Treatment can help manage symptoms and prevent flare-ups.

58. Rosacea Fulminans: Rosacea fulminans, also known as pyoderma faciale, is a severe and sudden form of rosacea characterized by painful, inflamed, and pus-filled nodules on the face. Prompt and aggressive treatment, usually with oral medications and topical therapies, is necessary to control the condition and prevent scarring.

59. Rosai-Dorfman Disease: Rosai-Dorfman disease is a rare non-cancerous condition characterized by the overproduction and accumulation of certain immune cells. In most cases, it resolves without treatment, but in some instances, surgical removal of lesions may be necessary.

60. Roseola-Viral Rash: Roseola, also known as sixth disease, is a common viral infection in young children that causes high fever followed by a characteristic rash. Supportive care, such as fever-reducing medications and fluids, helps manage the symptoms.

61. Rotator Cuff Tear: A rotator cuff tear is a common injury involving damage to the tendons of the shoulder’s rotator cuff muscles. Treatment may include rest, physical therapy, or in severe cases, surgical repair.

62. Rotavirus Infection: Rotavirus is a highly contagious virus that causes severe diarrhea and vomiting, primarily affecting young children. Preventive measures, such as vaccination and proper hygiene, can reduce the risk of infection.

63. RSV-Bronchiolitis: RSV bronchiolitis is a respiratory infection caused by the respiratory syncytial virus (RSV), primarily affecting infants and young children. Supportive care, such as hydration and fever management, is crucial for recovery.

64. Rubella: Rubella, also known as German measles, is a viral infection that can cause a rash, fever, and swollen lymph nodes. Vaccination is the most effective way to prevent rubella and its potential complications, especially during pregnancy.


I hope you found this article “Diseases That Start With R” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter R.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With S
  • Diseases That Start With T
  • Diseases That Start With U
  • Diseases That Start With V

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top