65 Diseases That Start With The Letter P

Have you ever wondered about diseases that start with the letter “P”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter P, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter P.


Diseases That Start With P

The followings are some known and lesser-known diseases that begin with the letter P (In alphabetical order):

1. Paget’s Disease

Paget’s Disease is a chronic bone disorder where abnormal bone remodeling occurs, leading to weakened and deformed bones, which can cause pain, fractures, and deformities.

2. Pancreatic Cancer

Pancreatic Cancer is a serious form of cancer that develops in the pancreas, an organ responsible for producing enzymes and hormones like insulin.

3. Pancreatitis

Pancreatitis is the inflammation of the pancreas, often caused by gallstones or excessive alcohol consumption. It can range from mild to severe and may require hospitalization.

4. Panic Attack

A Panic Attack is a sudden surge of intense fear or discomfort, often accompanied by physical symptoms like rapid heart rate, sweating, and trembling.

5. Panic Disorder

Panic Disorder is a type of anxiety disorder characterized by recurrent panic attacks and a constant fear of having future attacks.

6. Paratyphoid Fever

Paratyphoid Fever is a bacterial infection similar to typhoid fever but caused by different strains of Salmonella bacteria. It leads to symptoms like fever, headache, and gastrointestinal issues.

7. Parkinson’s Disease

Parkinson’s Disease is a progressive neurodegenerative disorder affecting movement, balance, and coordination, often leading to tremors and stiffness.

8. Patau’s Syndrome

Patau’s Syndrome, also known as Trisomy 13, is a genetic disorder caused by the presence of an extra chromosome 13. It leads to severe developmental abnormalities and is often fatal.

9. Patellar Tendinitis

Patellar Tendinitis, commonly called Jumper’s Knee, is the inflammation of the tendon that connects the kneecap (patella) to the shinbone.

10. Pelvic Floor Dysfunction

Pelvic Floor Dysfunction refers to the weakening or excessive tension in the pelvic floor muscles, leading to issues with bowel and bladder control, as well as pelvic pain.

11. Pelvic Inflammatory Disease

Pelvic Inflammatory Disease (PID) is an infection of the female reproductive organs, often caused by sexually transmitted infections (STIs).

12. Pelvic Organ Prolapse

Pelvic Organ Prolapse occurs when the pelvic organs, such as the bladder, uterus, or rectum, descend or bulge into the vaginal canal due to weakened pelvic muscles and ligaments.

13. Pemphigus

Pemphigus is a group of autoimmune disorders that cause blistering and erosion of the skin and mucous membranes.

14. Penile Cancer

Penile Cancer is a rare cancer that affects the penis, often developing in the skin or tissues of the organ.

15. Peptic Ulcer

Peptic Ulcer is a sore that forms on the lining of the stomach, small intestine, or esophagus, often caused by bacterial infection or long-term use of certain medications.

16. Period Pain

Period Pain, also known as dysmenorrhea, is the pain and discomfort experienced by some women during menstruation.

17. Peripheral Artery Disease (PAD)

Peripheral Artery Disease is a circulatory condition where narrowed arteries reduce blood flow to the limbs, usually the legs.

18. Peripheral Neuropathy

Peripheral Neuropathy is a condition in which the peripheral nerves that transmit signals between the central nervous system and the rest of the body become damaged, leading to various sensory and motor issues.

19. Peritonitis

Peritonitis is the inflammation of the peritoneum, the thin tissue that lines the abdominal cavity and covers the organs. It is often caused by infection or injury.

20. Pernicious Anemia

Pernicious Anemia is a type of anemia characterized by a deficiency of vitamin B12, often caused by the body’s inability to absorb this essential vitamin.

21. Personality Disorder

Personality Disorder refers to a group of mental health conditions characterized by rigid and unhealthy patterns of thinking, behavior, and functioning.

22. Pertussis (Whooping Cough)

Pertussis, commonly known as Whooping Cough, is a highly contagious bacterial infection that affects the respiratory system, causing severe coughing fits.

23. Peyronie’s Disease

Peyronie’s Disease is a condition in which scar tissue forms within the penis, leading to a bent or curved erection and potential pain during intercourse.

24. Pharyngitis

Pharyngitis is the inflammation of the throat (pharynx), often caused by viral or bacterial infections, resulting in a sore throat and difficulty swallowing.

25. Pica

Pica is an eating disorder characterized by the persistent craving and consumption of non-food items, such as clay, chalk, or dirt.

26. Pink Eye (Conjunctivitis)

Pink Eye, also known as Conjunctivitis, is an inflammation of the conjunctiva (the thin, transparent layer covering the white part of the eye and the inner surface of the eyelids), leading to redness, itching, and discharge from the eye.

27. Piroplasmosis

Piroplasmosis is a tick-borne disease that affects animals, particularly horses and dogs, and is caused by parasites of the genera Theileria and Babesia.

28. Plague

Plague is a highly infectious bacterial disease caused by the bacterium Yersinia pestis, primarily affecting rodents and transmitted to humans through flea bites.

29. Plantar Fasciitis

Plantar Fasciitis is a common condition characterized by pain and inflammation of the plantar fascia, a thick band of tissue that supports the arch of the foot.

30. Pleurisy

Pleurisy is the inflammation of the pleura, the two thin layers of tissue that surround the lungs, often causing chest pain and discomfort during breathing.

31. Pneumococcal Disease

Pneumococcal Disease refers to infections caused by the bacterium Streptococcus pneumoniae, leading to various illnesses like pneumonia, meningitis, and ear infections.

32. Pneumonia

Pneumonia is a lung infection that can be caused by viruses, bacteria, or fungi, leading to inflammation of the air sacs in the lungs and affecting breathing.

33. Polio

Polio, also known as Poliomyelitis, is a highly contagious viral infection that can cause paralysis and even death.

34. Polycystic Kidney Disease (PKD)

Polycystic Kidney Disease is a genetic disorder characterized by the growth of fluid-filled cysts in the kidneys, leading to kidney damage over time.

35. Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome is a hormonal disorder affecting women, leading to irregular menstrual cycles, excess hair growth, and potential fertility issues.

36. Polymyalgia Rheumatica

Polymyalgia Rheumatica is an inflammatory disorder causing pain and stiffness, primarily in the shoulders and hips.

37. Polyneuropathy

Polyneuropathy is a condition in which multiple peripheral nerves throughout the body become damaged or dysfunctional, leading to a range of sensory, motor, and autonomic symptoms.

38. Porphyria

Porphyria is a group of rare genetic disorders that affect the production of heme, a component of hemoglobin, leading to the buildup of certain chemicals that can cause various symptoms and complications.

39. Postnatal Depression

Postnatal Depression, also known as postpartum depression, is a type of mood disorder that occurs after childbirth, causing feelings of sadness, fatigue, and disinterest in daily activities.

40. Post-polio Syndrome

Post-polio Syndrome is a condition that affects some individuals who have had polio in the past, leading to new or worsening muscle weakness and fatigue.

41. Post-traumatic Stress Disorder (PTSD)

Post-traumatic Stress Disorder is a mental health condition triggered by experiencing or witnessing a traumatic event, leading to symptoms such as flashbacks, nightmares, and avoidance behavior.

42. Prader-Willi Syndrome

Prader-Willi Syndrome is a rare genetic disorder that affects multiple body systems, leading to intellectual disabilities, hyperphagia (excessive eating), and other developmental challenges.

43. Pre-Diabetes

Pre-Diabetes is a condition where blood sugar levels are higher than normal but not high enough to be classified as diabetes. It is a warning sign and an opportunity to prevent or delay the onset of type 2 diabetes.

44. Pregnancy

Pregnancy is a natural physiological process in which a fertilized egg develops into a fetus inside the uterus. It is a crucial time for maternal and fetal health, requiring proper prenatal care.

45. Premature Ejaculation

Premature Ejaculation is a sexual dysfunction where a man ejaculates sooner than desired during sexual intercourse, leading to distress and relationship issues.

46. Premature Menopause (Premature Ovarian Failure)

Premature Menopause, also known as Premature Ovarian Failure, refers to the cessation of menstruation and ovarian function before the age of 40, leading to infertility and hormonal changes.

47. Premenstrual Syndrome (PMS)

Premenstrual Syndrome is a combination of physical and emotional symptoms that occur before menstruation, affecting many women.

48. Presbyopia

Presbyopia is an age-related condition where the ability to focus on nearby objects decreases, leading to difficulty with tasks like reading or using smartphones.

49. Pressure Injury

Pressure Injury, previously known as pressure ulcer or bed sore, is a localized injury to the skin and underlying tissue, primarily caused by prolonged pressure on the skin.

50. Pressure Ulcers

Pressure Ulcers, also known as bedsores or decubitus ulcers, are wounds that develop due to continuous pressure on specific areas of the body, often seen in immobile or bedridden individuals.

51. Priapism

Priapism is a medical emergency characterized by a prolonged and painful erection that lasts for more than four hours and is not related to sexual arousal.

52. Primary Biliary Cholangitis (PBC)

Primary Biliary Cholangitis is a chronic liver disease that results from the inflammation and damage of the small bile ducts within the liver.

53. Primary Hypertension

Primary Hypertension, also known as essential hypertension, is high blood pressure with no identifiable cause, often linked to lifestyle and genetic factors.

54. Progressive Supranuclear Palsy (PSP)

Progressive Supranuclear Palsy is a rare neurological disorder affecting movement, balance, and cognition, leading to difficulties with walking, eye movements, and speech.

55. Prolapsed Disc (Herniated Disc)

Prolapsed Disc, also called Herniated Disc, occurs when the soft cushion-like discs between the vertebrae of the spine slip or rupture, causing pain and nerve compression.

56. Prostate Cancer

Prostate Cancer is a prevalent cancer that affects the prostate gland in men, often causing urinary difficulties and other symptoms.

57. Prostatitis

Prostatitis is the inflammation of the prostate gland, leading to pain and discomfort in the pelvic area and during urination.

58. Proteinuria

Proteinuria is the presence of an abnormally high amount of protein in the urine, which can indicate kidney damage or other health issues.

59. Psoriasis

Psoriasis is a chronic skin condition characterized by red, scaly patches of skin caused by an overactive immune system.

60. Psoriatic Arthritis

Psoriatic Arthritis is a form of inflammatory arthritis that affects some individuals with psoriasis, causing joint pain and swelling.

61. Psychosis

Psychosis is a severe mental health condition characterized by a loss of touch with reality, leading to hallucinations, delusions, and disorganized thinking.

62. Pubic Lice

Pubic Lice, also known as crabs, are parasitic insects that infest the pubic hair and other coarse body hair.

63. Pulmonary Edema

Pulmonary Edema is the accumulation of fluid in the lungs, leading to breathing difficulties and potential respiratory distress.

64. Pulmonary Embolism

Pulmonary Embolism occurs when a blood clot, often from the legs, travels to the lungs, blocking blood flow and posing a life-threatening condition.

65. Pyelonephritis

Pyelonephritis is a bacterial infection of the kidneys, often arising from a urinary tract infection and causing pain and fever.


I hope you found this article “Diseases That Start With P” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter P.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With Q
  • Diseases That Start With R
  • Diseases That Start With S
  • Diseases That Start With T

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