52 Diseases That Start With The Letter O

Have you ever wondered about diseases that start with the letter “O”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter O, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter O.


Diseases That Start With O

The followings are some known and lesser-known diseases that begin with the letter O (In alphabetical order):

1. Obesity

Obesity is a medical condition characterized by excessive body fat accumulation, leading to adverse effects on one’s health. It is often measured using the body mass index (BMI), and if left untreated, obesity can increase the risk of various health issues, including heart disease, diabetes, and joint problems.

2. Obsessive-Compulsive Disorder (OCD)

Obsessive-Compulsive Disorder is a mental health condition marked by recurring, intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Individuals with OCD often experience significant distress, and the condition can significantly interfere with daily life.

3. Obstipation

Obstipation refers to severe constipation that causes an inability to pass stool or gas. It is a distressing condition that may result from various underlying factors such as intestinal blockages or bowel motility issues.

4. Obstructive Sleep Apnea

Obstructive Sleep Apnea is a sleep disorder where the airway gets partially or completely blocked during sleep, leading to interrupted breathing and frequent awakenings. If untreated, it can contribute to daytime fatigue and other health problems.

5. Occupational Asthma

Occupational Asthma is a type of asthma triggered by workplace exposure to certain substances like chemicals, dust, or fumes. Symptoms may include coughing, wheezing, and shortness of breath.

6. Ocular Albinism

Ocular Albinism is a genetic condition that affects the eyes, causing reduced pigmentation in the iris, retina, and other eye structures. It may lead to vision problems, including reduced visual acuity and sensitivity to light.

7. Ocular Hypertension

Ocular Hypertension refers to higher-than-normal pressure within the eye, which can increase the risk of glaucoma if left untreated.

8. Ocular Hypotony

Ocular Hypotony is the opposite of ocular hypertension, where the intraocular pressure becomes abnormally low. It may be caused by various eye conditions or surgeries.

9. Ocular Melanoma

Ocular Melanoma, also known as uveal or choroidal melanoma, is a rare form of eye cancer that develops in the cells that produce eye pigmentation.

10. Ocular Migraine

Ocular Migraine is a type of migraine headache that involves visual disturbances without the typical head pain. It usually affects one eye and is usually harmless, although it can be alarming.

11. Ocular Myasthenia Gravis

Ocular Myasthenia Gravis is a neuromuscular disorder that primarily affects the muscles of the eyes, leading to weakness and fatigue.

12. Ocular Rosacea

Ocular Rosacea is an eye condition linked to skin rosacea, causing redness, irritation, and dryness in the eyes.

13. Oculomotor Nerve Palsy

Oculomotor Nerve Palsy is a neurological condition that affects the eye muscles, leading to double vision, drooping eyelids, and difficulty focusing.

14. Oculopharyngeal Muscular Dystrophy

Oculopharyngeal Muscular Dystrophy is a rare genetic disorder characterized by progressive weakness in the eye, face, and throat muscles.

15. Oesophageal Cancer

Oesophageal Cancer is a malignancy that develops in the esophagus, the muscular tube connecting the throat to the stomach.

16. Olfactory Neuroblastoma

Olfactory Neuroblastoma is a rare cancer that originates in the olfactory nerve, which is responsible for the sense of smell.

17. Oligodendroglioma

Oligodendroglioma is a type of brain tumor that arises from oligodendrocytes, a type of brain cell.

18. Oliguria

Oliguria is a medical condition characterized by reduced urine output, often caused by kidney-related issues.

19. Ondine Curse (Congenital Central Hypoventilation Syndrome)

Ondine Curse, also known as Congenital Central Hypoventilation Syndrome, is a rare disorder affecting the autonomic nervous system’s control of breathing, leading to hypoventilation during sleep.

20. Onycholysis

Onycholysis is a condition where the nails detach from the nail bed, often caused by trauma or fungal infections.

21. Onychomycosis (Nail Fungus)

Onychomycosis, commonly known as Nail Fungus, is a fungal infection that affects the nails, causing discoloration and thickening.

22. Open Cholecystectomy

Open Cholecystectomy is a surgical procedure to remove the gallbladder through a large incision in the abdomen.

23. Ophthalmoplegia

Ophthalmoplegia is a condition characterized by paralysis or weakness of the eye muscles, leading to difficulty moving the eyes.

24. Opioid Use Disorder

Opioid Use Disorder is a chronic condition marked by the compulsive use of opioids, despite negative consequences.

25. Opsoclonus-Myoclonus Syndrome

Opsoclonus-Myoclonus Syndrome is a rare neurological disorder characterized by sudden, involuntary eye movements (opsoclonus) and muscle jerks (myoclonus).

26. Optic Neuritis

Optic Neuritis is the inflammation of the optic nerve, causing vision loss, eye pain, and reduced color vision.

27. Oral Cancer

Oral Cancer refers to malignancies that develop in the oral cavity, including the lips, tongue, cheeks, and throat.

28. Oral Herpes (Cold Sores)

Oral Herpes, also known as Cold Sores, is a viral infection caused by the herpes simplex virus, leading to painful blisters around the mouth.

29. Oral Thrush

Oral Thrush is a fungal infection caused by Candida yeast, resulting in white patches on the tongue and mouth.

30. Orbital Cellulitis

Orbital Cellulitis is a serious infection of the tissues around the eye, often caused by bacteria spreading from the sinuses.

31. Orchitis

Orchitis is the inflammation of the testicles, typically caused by a viral infection such as mumps.

32. Oropharyngeal Cancer

Oropharyngeal Cancer is a type of head and neck cancer that affects the back of the throat, tonsils, and base of the tongue.

33. Orotic Aciduria

Orotic Aciduria is a rare metabolic disorder that affects the production and elimination of uridine monophosphate, leading to various health issues.

34. Orthostatic Hypotension

Orthostatic Hypotension is a sudden drop in blood pressure that occurs when standing up, causing dizziness and fainting.

35. Osgood-Schlatter Disease

Osgood-Schlatter Disease is a condition that causes knee pain and swelling, commonly seen in growing adolescents involved in sports.

36. Osler Disease (Hereditary Hemorrhagic Telangiectasia)

Osler Disease, also known as Hereditary Hemorrhagic Telangiectasia (HHT), is a genetic disorder that leads to abnormal blood vessel formation, causing telangiectasias (small, fragile blood vessels) that can bleed and cause various complications.

37. Ossicular Chain Dislocation

Ossicular Chain Dislocation refers to the misalignment or displacement of the tiny bones in the middle ear, which can result from trauma or infection, leading to conductive hearing loss.

38. Osteoarthritis

Osteoarthritis is the most common form of arthritis, characterized by the degeneration of joint cartilage, leading to pain, stiffness, and reduced joint mobility.

39. Osteochondroma

Osteochondroma is a benign bone tumor that forms on the surface of bones near the growth plate.

40. Osteogenesis Imperfecta (Brittle Bone Disease)

Osteogenesis Imperfecta is a genetic disorder characterized by fragile and easily broken bones, often resulting from a deficiency in collagen production.

41. Osteolysis

Osteolysis refers to the loss or destruction of bone tissue, often associated with certain medical conditions or implant complications.

42. Osteomalacia

Osteomalacia is a softening of the bones due to a vitamin D deficiency, leading to weak and painful bones.

43. Osteopetrosis

Osteopetrosis, also known as marble bone disease, is a rare genetic condition characterized by increased bone density, which can lead to bone fractures and other complications.

44. Osteosarcoma

Osteosarcoma is a rare but aggressive form of bone cancer that commonly affects young people and adolescents.

45. Otitis Externa (Swimmer’s Ear)

Otitis Externa, commonly known as Swimmer’s Ear, is an infection of the outer ear canal, often caused by water exposure.

46. Otitis Media (Ear Infection)

Otitis Media is an infection or inflammation of the middle ear, commonly seen in children and often associated with upper respiratory infections.

47. Ovarian Cancer

Ovarian Cancer is a type of cancer that originates in the ovaries, the female reproductive organs that produce eggs.

48. Ovarian Cyst

Ovarian Cysts are fluid-filled sacs that can form on or inside the ovaries, often causing pain or discomfort.

49. Ovarian Germ Cell Tumor

Ovarian Germ Cell Tumor is a type of ovarian cancer that develops from the cells that produce eggs.

50. Ovarian Hyperstimulation Syndrome (OHSS)

Ovarian Hyperstimulation Syndrome can occur as a complication of fertility treatments, where the ovaries become swollen and painful due to hormonal stimulation.

51. Ovarian Torsion

Ovarian Torsion is a medical emergency that happens when the ovary twists on its supporting ligaments, leading to severe pain and potential damage to the ovary.

52. Overactive Thyroid

Overactive Thyroid, also known as hyperthyroidism, occurs when the thyroid gland produces an excess of thyroid hormones, leading to various symptoms like weight loss, anxiety, and rapid heart rate.


I hope you found this article “Diseases That Start With O” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter O.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With P
  • Diseases That Start With Q
  • Diseases That Start With R
  • Diseases That Start With S

Munshur A

Munshur A is the man behind learningandliving.net. An automobile engineer and passionate blogger, who loves to learn and share new things with his reader.

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