81 Diseases That Start With The Letter E

Have you ever wondered about diseases that start with the letter “E”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter E, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter E.


Diseases That Start With E

The followings are some known and lesser-known diseases that begin with the letter E (In alphabetical order):

1. E. Coli: E. Coli is a type of bacteria that commonly resides in the intestines of humans and animals. While most strains are harmless, some can cause severe foodborne illnesses leading to symptoms such as abdominal cramps, diarrhea, and vomiting. Ensuring proper food hygiene and handwashing can help prevent E. Coli infections.

2. Ear – Congestion: Ear congestion occurs when the Eustachian tube, which connects the middle ear to the back of the throat, becomes blocked. This condition often accompanies colds, allergies, or sinus infections, causing discomfort and hearing difficulties. Home remedies like warm compresses and over-the-counter decongestants may provide relief.

3. Ear – Discharge: Ear discharge, also known as otorrhea, is the secretion of fluid or pus from the ear. It can result from infections, injuries, or foreign objects in the ear canal. Prompt medical evaluation is essential to determine the underlying cause and appropriate treatment.

4. Ear – Pulling At or Rubbing: Young children may tug at or rub their ears when they experience ear pain or discomfort. This behavior is often a sign of ear infections, and seeking medical attention is crucial to address the underlying issue.

5. Ear – Swimmer’s: Swimmer’s ear is an infection of the ear canal that occurs when water gets trapped in the ear, creating a moist environment ideal for bacterial growth. It leads to ear pain, redness, and sometimes discharge. Drying the ears thoroughly after swimming can help prevent this condition.

6. Ear Injury: Ear injuries can result from various accidents, trauma, or exposure to loud noises. Depending on the severity, ear injuries may cause hearing loss, pain, or bleeding. Seeking immediate medical care is vital to prevent complications.

7. Ear Piercing Symptoms: After getting an ear piercing, it is common to experience mild swelling, redness, and tenderness around the pierced area. Proper aftercare, such as keeping the piercing clean, is essential to prevent infections.

8. Earache: Earaches can be caused by infections, sinus problems, or dental issues, leading to discomfort and pain in the ear. Identifying the underlying cause and appropriate treatment is crucial to alleviate the pain.

9. Earwax Buildup: Earwax is a natural substance that protects the ear canal, but excessive buildup can lead to hearing problems and discomfort. Avoid using cotton swabs to clean the ears, as it can push the wax deeper. Instead, consult a healthcare professional for safe removal.

10. Eating Disorders: Eating disorders like anorexia nervosa, bulimia nervosa, and binge eating disorder are serious mental health conditions that affect a person’s relationship with food and body image. Seeking professional help is essential for effective treatment and recovery.

11. Ebola: Ebola is a rare but severe viral disease that causes hemorrhagic fever, leading to internal bleeding and organ failure. Strict infection control measures are necessary to prevent its spread, and early medical intervention is crucial for survival.

12. Ebola Exposure: If someone has been in close contact with a person infected with Ebola or exposed to contaminated materials, they are at risk of contracting the virus. Immediate isolation and medical evaluation are necessary to prevent potential transmission.

13. Ebstein’s Anomaly: Ebstein’s anomaly is a congenital heart defect where the tricuspid valve is abnormally positioned, leading to blood flow issues in the heart. Treatment options depend on the severity of the condition and may include medications or surgery.

14. Echinococcosis: Echinococcosis, also known as hydatid disease, is a parasitic infection that primarily affects the liver and lungs. It is crucial to treat this condition promptly to prevent complications like cyst rupture and secondary infections.

15. Eclampsia: Eclampsia is a life-threatening complication of pregnancy characterized by seizures and high blood pressure. Immediate medical attention is essential for both the safety of the mother and the baby.

16. Ectopia Cordis: Ectopia cordis is a rare congenital condition where the heart develops outside the chest cavity. Surgery is often required soon after birth to place the heart back into the chest and protect it with a protective covering.

17. Ectopic Pregnancy: Ectopic pregnancy occurs when a fertilized egg implants outside the uterus, usually in the fallopian tube. It is a medical emergency that requires immediate treatment to prevent complications.

18. Eczema: Eczema, or atopic dermatitis, is a chronic skin condition characterized by itchy, inflamed, and red patches of skin. Managing triggers and using moisturizers can help control symptoms.

19. Edema: Edema is the swelling caused by the accumulation of fluid in the body’s tissues. It can be a symptom of an underlying health condition and may require medical evaluation.

20. Edwards Syndrome (Trisomy 18): Edwards syndrome is a chromosomal disorder where a person has an extra copy of chromosome 18. It leads to developmental and medical complications, and sadly, many babies born with this condition do not survive past infancy.

21. Ehlers-Danlos Syndrome: Ehlers-Danlos Syndrome (EDS) is a group of connective tissue disorders characterized by joint hypermobility, skin that is easily bruised and stretched, and increased fragility of blood vessels. Depending on the type of EDS, symptoms can vary, and there is no cure, but management focuses on symptom relief and preventing complications.

22. Ehrlichia Infection: Ehrlichia infection is a tick-borne illness caused by Ehrlichia bacteria. Symptoms include fever, headache, fatigue, and muscle aches. Timely treatment with antibiotics is crucial to prevent the infection from progressing to a severe form.

23. Ehrlichiosis: Ehrlichiosis is a tick-borne disease caused by Ehrlichia chaffeensis or Ehrlichia ewingii. Symptoms are similar to the flu, including fever, chills, muscle aches, and headache. Early diagnosis and treatment are essential to prevent complications.

24. Elbow Sprain: An elbow sprain refers to the stretching or tearing of ligaments around the elbow joint. Rest, ice, compression, and elevation (RICE) and physical therapy are commonly used to promote healing.

25. Elephantiasis: Elephantiasis, also known as lymphatic filariasis, is a parasitic disease transmitted by mosquitoes. It causes severe swelling and thickening of the skin and underlying tissues, mainly in the legs and genital area. Preventive measures and treatment can help manage the symptoms.

26. Emphysema: Emphysema is a type of chronic obstructive pulmonary disease (COPD) characterized by damage to the air sacs in the lungs, leading to breathing difficulties. Quitting smoking and using inhalers are some ways to manage this condition.

27. Encephalitis: Encephalitis is inflammation of the brain, often caused by viral infections. Symptoms can range from mild to severe, and immediate medical attention is essential for proper diagnosis and treatment.

28. Encephalocele: Encephalocele is a birth defect where a portion of the brain protrudes through an opening in the skull. Surgery is typically required to repair the defect and protect the brain.

29. Encephalopathy: Encephalopathy is a broad term for brain dysfunction or damage. Causes can include infections, toxins, and metabolic disorders. Treatment aims to address the underlying cause and manage symptoms.

30. Encopresis: Encopresis is the involuntary passing of stool in children who are beyond the age of toilet training. It can be caused by constipation and emotional factors. A combination of dietary changes, behavioral therapy, and laxatives may be used for treatment.

31. Endocarditis: Endocarditis is inflammation of the inner lining of the heart chambers and valves. It is often caused by bacterial infections and requires prompt medical attention and long-term antibiotic treatment.

32. Endometrial Cancer: Endometrial cancer is cancer that starts in the lining of the uterus. Early diagnosis and treatment, which may involve surgery, radiation, or chemotherapy, can improve the prognosis.

33. Endometriosis: Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus. It can cause pain and fertility problems. Treatment options include medications and surgery.

34. Endoscopy: Endoscopy is a medical procedure that involves inserting a flexible tube with a camera into the body to examine the internal organs or tissues. It is commonly used for diagnostic purposes and minor surgeries.

35. End-Stage Renal Disease (ESRD): End-stage renal disease is the final stage of chronic kidney disease when the kidneys have lost nearly all their function. Dialysis or kidney transplant becomes necessary for survival.

36. Enlarged Heart: Enlarged heart, also known as cardiomegaly, is a condition where the heart becomes larger than normal due to various underlying causes. Treatment focuses on managing the underlying condition and preventing complications.

37. Enteric Fever: Enteric fever, also called typhoid fever, is a bacterial infection caused by Salmonella typhi. It leads to fever, abdominal pain, and gastrointestinal symptoms. Antibiotics are used for treatment.

38. Enteritis: Enteritis is inflammation of the small intestine, usually caused by infections or inflammatory conditions. Rest, fluids, and medications are used to manage symptoms and promote healing.

39. Enterohaemorrhagic Escherichia Coli (EHEC) Infection: EHEC infection is a severe type of E. coli infection that can lead to bloody diarrhea and, in severe cases, kidney failure. Hydration and medical management are crucial for recovery.

40. Enterovirus: Enteroviruses are a group of viruses that can cause a wide range of illnesses, from mild respiratory infections to severe neurological diseases. Prevention involves good hygiene practices.

41. Epidemic Louse-borne Typhus: Epidemic louse-borne typhus is a rare bacterial disease transmitted by lice. It causes flu-like symptoms and can be treated with antibiotics.

42. Epidermoid Cyst: Epidermoid cysts are non-cancerous, small bumps that form beneath the skin. They are usually harmless but can be removed if they cause discomfort.

43. Epidermolysis Bullosa: Epidermolysis bullosa is a group of rare genetic disorders that cause the skin to be fragile and prone to blisters. There is no cure, but treatment focuses on managing symptoms and preventing complications.

44. Epididymitis: Epididymitis is inflammation of the epididymis, a tube at the back of the testicles that carries and stores sperm. Antibiotics are used to treat infections that cause epididymitis.

45. Epidural Hematoma: Epidural hematoma is a serious condition where blood accumulates between the skull and the protective covering of the brain. Immediate medical intervention is necessary to relieve the pressure on the brain.

46. Epiglottic Abscess: Epiglottic abscess is a rare infection that causes swelling and inflammation of the epiglottis, the flap-like structure at the base of the tongue. It can cause breathing difficulties and requires urgent medical attention.

47. Epiglottitis: Epiglottitis is a potentially life-threatening condition where the epiglottis becomes inflamed, blocking the airway. It is most commonly caused by bacteria, and treatment may include airway management and antibiotics.

48. Epilepsy: Epilepsy is a neurological disorder characterized by recurrent seizures. Treatment involves medications to control seizures and lifestyle adjustments.

49. Epiretinal Membrane: Epiretinal membrane is a thin layer of scar tissue that forms on the retina. It can cause vision distortion and, in severe cases, require surgical intervention.

50. Epispadias: Epispadias is a congenital condition where the opening of the urethra is on the upper side of the penis. Surgical correction is usually required.

51. Epithelioid Sarcoma: Epithelioid sarcoma is a rare and aggressive form of soft tissue cancer. Treatment typically involves surgery to remove the tumor, followed by radiation therapy and chemotherapy to target any remaining cancer cells.

52. Epstein-Barr Virus (EBV) Infection: Epstein-Barr virus is a common virus that causes infectious mononucleosis, also known as mono. It spreads through saliva and can lead to flu-like symptoms, swollen lymph nodes, and fatigue. Rest, fluids, and pain relievers are often recommended for symptom relief.

53. Erdheim-Chester Disease: Erdheim-Chester disease is an extremely rare non-Langerhans cell histiocytosis that affects multiple organs. Treatment options depend on the affected organs and may include surgery, radiation, or medications.

54. Erectile Dysfunction: Erectile dysfunction is the inability to achieve or maintain an erection sufficient for sexual activity. It can have physical or psychological causes and can be managed with medications, counseling, or lifestyle changes.

55. Eructation (Burping): Eructation, commonly known as burping, is the release of gas from the digestive system through the mouth. It is a normal bodily function that helps relieve discomfort caused by excess gas.

56. Erysipelas: Erysipelas is a skin infection caused by bacteria, often affecting the face or legs. It leads to red, swollen, and painful skin. Antibiotics are typically prescribed for treatment.

57. Erythema Multiforme: Erythema multiforme is a skin condition characterized by target-like skin lesions, usually triggered by infections or medications. Treatment focuses on managing the underlying cause and symptoms.

58. Erythrasma: Erythrasma is a bacterial skin infection that causes red, scaly patches in skin folds. It is usually treated with topical or oral antibiotics.

59. Erythroplakia: Erythroplakia is a red patch in the mouth that can be a precancerous condition. It requires thorough evaluation and monitoring by a dentist or oral specialist.

60. Escherichia coli (E. coli) O157: E. coli O157 is a specific strain of E. coli bacteria that can cause severe foodborne illnesses and may lead to kidney failure in some cases. Preventing contamination during food preparation and proper hygiene are essential for prevention.

61. Esophageal Cancer: Esophageal cancer is cancer that develops in the esophagus. Treatment options depend on the stage and may include surgery, chemotherapy, and radiation therapy.

62. Esophageal Varices: Esophageal varices are enlarged veins in the esophagus that occur in individuals with liver disease. They can be life-threatening if they rupture and require medical management.

63. Esophagitis: Esophagitis is inflammation of the esophagus, often caused by acid reflux. Lifestyle changes, medications, and avoiding trigger foods can help manage the condition.

64. Essential Thrombocythemia: Essential thrombocythemia is a disorder characterized by the overproduction of platelets in the blood. Treatment may include medications and blood thinners to reduce the risk of blood clots.

65. Essential Tremor: Essential tremor is a neurological disorder that causes involuntary shaking, most commonly in the hands. Medications and physical therapy can help manage the symptoms.

66. Eumycetoma: Eumycetoma is a chronic and progressive fungal infection that affects the skin and underlying tissues. Antifungal medications are used for treatment.

67. Evans Syndrome: Evans syndrome is a rare autoimmune disorder where the immune system attacks red blood cells, white blood cells, and platelets. Treatment focuses on managing the symptoms and preventing complications.

68. Ewing Sarcoma: Ewing sarcoma is a rare bone cancer that primarily affects children and young adults. Treatment often involves a combination of surgery, chemotherapy, and radiation therapy.

69. Exanthem Subitum (Roseola): Exanthem subitum, also known as roseola, is a viral infection common in young children. It causes high fever followed by a rash. Usually, no specific treatment is required as the infection resolves on its own.

70. Exfoliative Dermatitis: Exfoliative dermatitis is a severe skin condition where large areas of the skin become red, inflamed, and peel off. Hospitalization and treatment with medications are necessary to manage the condition.

71. Exotropia: Exotropia is a type of strabismus or “lazy eye” where one eye turns outward. It may be treated with eyeglasses, eye patches, or surgery.

72. External Otitis: External otitis, commonly known as swimmer’s ear, is inflammation of the ear canal often caused by bacterial infection. It is treated with ear drops containing antibiotics and steroids.

73. Eye – Allergy: Eye allergies, also called allergic conjunctivitis, cause redness, itching, and watering of the eyes. Antihistamine eye drops and avoiding allergens can help manage symptoms.

74. Eye – Foreign Object: Getting a foreign object in the eye can be painful and potentially damaging. If not easily removed, seeking medical attention is important to prevent further injury.

75. Eye – Pus or Discharge: Pus or discharge from the eye may indicate an eye infection. Proper hygiene and seeking medical evaluation are crucial to prevent the spread of infection.

76. Eye – Red Without Pus: Redness in the eyes without discharge can be caused by various factors, including eye strain, dryness, or allergies. Resting the eyes and using artificial tears may provide relief.

77. Eye Cancer: Eye cancer can affect different parts of the eye, including the retina and the eye’s surface. Early diagnosis and treatment are essential for preserving vision and preventing the cancer from spreading.

78. Eye Conditions: Various eye conditions, such as cataracts, glaucoma, and macular degeneration, can impact vision and require different forms of treatment. Regular eye check-ups are crucial for early detection and management.

79. Eye Injury: Eye injuries, ranging from minor scratches to severe trauma, require immediate medical evaluation to prevent vision loss and complications.

80. Eye Strain: Eye strain is a common condition caused by prolonged use of digital devices or reading without breaks. Taking regular breaks and adjusting screen brightness can help alleviate symptoms.

81. Eye Swelling: Eye swelling can result from allergies, infections, or injuries. Applying a cold compress and seeking medical attention if the swelling is severe or accompanied by vision changes is important.


I hope you found this article “Diseases That Start With E” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter E.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With F
  • Diseases That Start With G
  • Diseases That Start With H
  • Diseases That Start With I

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