69 Diseases That Start With The Letter D

Have you ever wondered about diseases that start with the letter “D”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter D, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter D.


Diseases That Start With D

The followings are some known and lesser-known diseases that begin with the letter D (In alphabetical order):

1. Dacryocystitis: Dacryocystitis is an infection of the tear sac, leading to pain, redness, and swelling near the inner corner of the eye. Antibiotics and warm compresses are typically used for treatment, and in some cases, surgery may be required to clear the blockage.

2. Deafblindness: Deafblindness refers to a condition where an individual has both visual and hearing impairments. Depending on the severity, individuals with deafblindness may benefit from assistive devices and specialized education.

3. Deep Vein Thrombosis (DVT): Deep vein thrombosis is a blood clot that forms in a deep vein, often in the legs. If not treated promptly, DVT can lead to serious complications. Anticoagulant medications are used to prevent the clot from growing and reduce the risk of it breaking loose and causing a pulmonary embolism.

4. Degenerative Disc Disease: Degenerative disc disease is a condition where the intervertebral discs in the spine deteriorate, causing pain and reduced mobility. Treatment may involve pain management, physical therapy, and, in severe cases, surgery.

5. Dehydration: Dehydration occurs when the body loses more fluids than it takes in, leading to an imbalance of electrolytes. It can be caused by various factors, including illness and insufficient fluid intake. Rehydration with oral fluids or intravenous fluids may be necessary in severe cases.

6. Delayed Sleep Phase Disorder (DSPD): DSPD is a sleep disorder where an individual’s sleep-wake cycle is significantly delayed compared to the conventional day-night schedule. Treatment involves sleep hygiene practices, light therapy, and sometimes medication to regulate sleep patterns.

7. Delirium: Delirium is a sudden onset of confusion and disorientation, often caused by an underlying medical condition or medication. Identifying and treating the underlying cause is essential for managing delirium.

8. Delirium Tremens (DT): Delirium tremens is a severe form of alcohol withdrawal, characterized by hallucinations, tremors, and extreme confusion. It requires immediate medical attention, and treatment includes supportive care and medication to manage symptoms.

9. Delusional Disorder: Delusional disorder is a mental health condition where an individual holds false and irrational beliefs despite evidence to the contrary. Psychotherapy and medications may be used for treatment.

10. Delusional Parasitosis: Delusional parasitosis is a psychiatric condition where an individual firmly believes they are infested with parasites, despite no evidence of infestation. Treatment involves psychiatric evaluation and therapy.

11. Dementia: Dementia refers to a group of cognitive disorders characterized by memory loss and impaired thinking abilities. Management includes cognitive stimulation, lifestyle adjustments, and, in some cases, medications.

12. Demyelinating Diseases: Demyelinating diseases, such as multiple sclerosis, involve damage to the protective myelin sheath surrounding nerve fibers. Treatment aims to slow disease progression and manage symptoms.

13. Dengue: Dengue is a mosquito-borne viral infection that can cause flu-like symptoms and, in severe cases, dengue hemorrhagic fever or dengue shock syndrome. Supportive care, rest, and hydration are important for managing dengue.

14. Dengue Fever: Dengue fever is the milder form of dengue infection, characterized by symptoms like fever, headache, and joint pain. Adequate rest and hydration are essential for recovery.

15. Dental Abscess: A dental abscess is a painful pocket of pus that can form in the teeth or gums due to bacterial infection. Treatment may involve draining the abscess and, in some cases, root canal treatment or tooth extraction.

16. Depression: Depression is a mood disorder characterized by persistent sadness and loss of interest in activities. Psychotherapy, medication, and lifestyle changes are commonly used for treatment.

17. Dermal Ulcer: Dermal ulcers are open sores on the skin caused by poor circulation, pressure, or other underlying health conditions. Proper wound care and addressing the underlying cause are essential for healing.

18. Dermatitis: Dermatitis refers to inflammation of the skin, often caused by allergic reactions or irritants. Avoiding triggers and using topical corticosteroids can help manage dermatitis.

19. Dermatitis Herpetiformis: Dermatitis herpetiformis is a skin condition associated with celiac disease, characterized by itchy, blistering skin rashes. A gluten-free diet is the primary treatment for managing symptoms.

20. Dermatomyositis: Dermatomyositis is an inflammatory muscle and skin disease that can cause muscle weakness and skin rashes. Treatment may involve medications to control inflammation.

21. Dermoid Cyst: A dermoid cyst is a benign growth containing tissues like hair, skin, or teeth. Surgical removal is typically recommended to prevent complications.

22. Detached Retina: A detached retina occurs when the retina peels away from the back of the eye, leading to vision loss. Immediate surgery is needed to reattach the retina and restore vision.

23. Developmental Dysplasia of the Hip (DDH): Developmental dysplasia of the hip is a condition where the hip joint is not properly formed. Treatment may involve bracing or surgery to correct the alignment of the hip joint.

24. Deviated Septum: A deviated septum is a condition where the nasal septum is displaced to one side, leading to breathing difficulties. Surgery may be recommended to straighten the septum.

25. DHF: DHF stands for dengue hemorrhagic fever, a severe form of dengue infection that can cause bleeding, organ failure, and shock. Immediate medical intervention and supportive care are crucial for managing DHF.

26. Diabetes: Diabetes is a metabolic disorder characterized by high blood sugar levels. Management involves blood sugar monitoring, lifestyle changes, and, in some cases, insulin or oral medications.

27. Diabetic Foot Ulcer: Diabetic foot ulcers are open sores on the feet caused by nerve damage and poor circulation in individuals with diabetes. Proper wound care and blood sugar control are essential for healing.

28. Diabetic Gastroparesis: Diabetic gastroparesis is a condition where the stomach takes longer than usual to empty, leading to digestive problems. Dietary changes and medications may be used for management.

29. Diabetic Ketoacidosis (DKA): DKA is a life-threatening complication of diabetes characterized by high blood sugar levels and the presence of ketones in the blood. Immediate medical attention and insulin treatment are necessary.

30. Diabetic Macular Edema: Diabetic macular edema is a complication of diabetic retinopathy, where fluid accumulates in the macula, causing vision loss. Treatment includes laser therapy and medication injections.

31. Diabetic Nephropathy: Diabetic nephropathy is kidney damage caused by diabetes. Blood pressure control and blood sugar management are crucial for slowing the progression of the disease.

32. Diabetic Neuropathy: Diabetic neuropathy is nerve damage caused by diabetes, leading to tingling, numbness, and pain in the extremities. Blood sugar control and pain management are important for treating diabetic neuropathy.

33. Diabetic Retinopathy: Diabetic retinopathy is damage to the blood vessels in the retina, leading to vision impairment. Regular eye exams and blood sugar control are essential for preventing or slowing its progression.

34. Diamond-Blackfan Anemia (DBA): Diamond-Blackfan anemia is a rare blood disorder affecting red blood cell production. Treatment may involve blood transfusions, steroids, and, in severe cases, bone marrow transplant.

35. Diaper Rash: Diaper rash is a common skin irritation that affects infants and toddlers. Keeping the diaper area clean and dry and using diaper rash creams can help soothe the rash.

36. Diarrhea: Diarrhea is a common digestive problem characterized by loose, watery stools. It is often caused by infections, food intolerance, or medications. Hydration and addressing the underlying cause are essential for management.

37. Diarrhoea: Diarrhoea refers to frequent and watery bowel movements, often caused by gastrointestinal infections or food poisoning. Rest, hydration, and symptomatic relief are important for recovery.

38. Diphtheria: Diphtheria is a bacterial infection that can cause severe respiratory problems. Vaccination is the most effective way to prevent diphtheria.

39. Discoid Eczema: Discoid eczema is a type of eczema characterized by coin-shaped patches of inflamed skin. Moisturizers and topical corticosteroids are commonly used for treatment.

40. Discoid Lupus Erythematosus (DLE): Discoid lupus erythematosus is a chronic autoimmune condition affecting the skin, causing red, scaly rashes. Sun protection and topical medications are used for management.

41. Dislocation: Dislocation occurs when a bone slips out of its normal position in a joint. Reducing the dislocation and immobilizing the joint are essential for treatment.

42. Disruptive Mood Dysregulation Disorder (DMDD): DMDD is a mood disorder in children characterized by severe temper outbursts and irritability. Therapy and medication may be used for management.

43. Disseminated Intravascular Coagulation (DIC): DIC is a serious condition where blood clotting and bleeding occur simultaneously throughout the body. Treatment focuses on addressing the underlying cause and stabilizing blood clotting.

44. Diverticulitis: Diverticulitis is inflammation or infection of small pouches that can form in the walls of the colon. Treatment may involve antibiotics, dietary changes, and, in severe cases, surgery.

45. Dizziness: Dizziness is a sensation of lightheadedness or unsteadiness. It can be caused by various factors, including inner ear problems or low blood pressure. Treating the underlying cause is crucial for managing dizziness.

46. Double-Inlet Left Ventricle: Double-inlet left ventricle is a congenital heart defect where both the pulmonary and systemic blood flow enters the left ventricle. Surgery is typically required to correct the condition.

47. Double-Outlet Right Ventricle: Double-outlet right ventricle is a congenital heart defect where both the pulmonary and systemic blood flow exits the right ventricle. Surgery is needed to correct the condition.

48. Down Syndrome: Down syndrome is a genetic disorder caused by the presence of an extra chromosome 21. Early intervention, therapy, and support are essential for individuals with Down syndrome.

49. Drug Allergy: A drug allergy occurs when the immune system reacts to a medication, leading to various symptoms, such as rash, itching, or anaphylaxis. Avoiding the allergenic drug and using alternative medications are crucial.

50. Drug-Induced Liver Injury (DILI): Drug-induced liver injury refers to liver damage caused by certain medications. Stopping the offending medication and supportive care are vital for managing DILI.

51. Drug-Resistant Tuberculosis (DR-TB): DR-TB is a form of tuberculosis that is resistant to standard tuberculosis medications. Treatment involves a combination of multiple drugs for an extended period.

52. Dry Mouth: Dry mouth, or xerostomia, is a condition where the salivary glands do not produce enough saliva. Maintaining good oral hygiene and staying hydrated can help manage dry mouth.

53. Dry Skin: Dry skin is a common skin condition that can be caused by various factors, such as cold weather or excessive bathing. Moisturizing and avoiding harsh soaps are essential for managing dry skin.

54. Duchenne Muscular Dystrophy (DMD): Duchenne muscular dystrophy is a genetic disorder affecting muscle strength and function. Physical therapy and supportive care can help manage symptoms.

55. Duodenal Ulcer: A duodenal ulcer is a sore that develops on the lining of the duodenum. Treatment may involve medications to reduce stomach acid and promote healing.

56. Dupuytren’s Contracture: Dupuytren’s contracture is a condition where the fingers bend toward the palm due to thickening of connective tissue. Surgery may be required to correct the contracture.

57. Dwarfism: Dwarfism is a medical condition characterized by short stature. Management involves addressing underlying medical issues and providing support and resources for individuals with dwarfism.

58. Dwarfism and Skeletal Dysplasias: Skeletal dysplasias are a group of genetic disorders that affect bone and cartilage development, leading to various forms of dwarfism. Treatment aims to manage symptoms and improve quality of life.

59. Dysautonomia: Dysautonomia refers to dysfunction of the autonomic nervous system, leading to various symptoms such as rapid heart rate, fainting, and temperature regulation problems. Management involves symptom-specific treatments.

60. Dysentery: Dysentery is a bacterial or parasitic infection of the intestines, causing severe diarrhea with blood and mucus. Hydration and antibiotics are important for managing dysentery.

61. Dysfunctional Uterine Bleeding (DUB): DUB is abnormal bleeding from the uterus that is not related to menstruation. Treatment depends on the underlying cause and may include hormonal medications.

62. Dysgerminoma: Dysgerminoma is a type of ovarian germ cell tumor. Treatment typically involves surgical removal and, in some cases, chemotherapy.

63. Dysgraphia: Dysgraphia is a learning disability that affects a person’s ability to write coherently. Accommodations and specialized education can help individuals with dysgraphia.

64. Dyshidrosis: Dyshidrosis is a skin condition characterized by small, itchy blisters on the palms and soles. Topical creams and lifestyle changes may be used for management.

65. Dyskeratosis Congenita: Dyskeratosis congenita is a rare genetic disorder affecting multiple systems in the body. Management involves addressing specific symptoms and complications.

66. Dyslexia: Dyslexia is a learning disorder that affects reading and language processing. Early intervention and specialized education can help individuals with dyslexia.

67. Dyspepsia: Dyspepsia, also known as indigestion, refers to discomfort or pain in the upper abdomen. Dietary changes and medications may be used for management.

68. Dysthymia: Dysthymia is a persistent mild form of depression. Therapy and medication may be used for managing dysthymia.

69. Dystonia: Dystonia is a movement disorder characterized by involuntary muscle contractions. Treatment may involve medications, botulinum toxin injections, and physical therapy.


I hope you found this article “Diseases That Start With D” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter D.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With E
  • Diseases That Start With F
  • Diseases That Start With G
  • Diseases That Start With H

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