70 Diseases That Start With The Letter M

Have you ever wondered about diseases that start with the letter “M”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter M, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter M.


Diseases That Start With M

The followings are some known and lesser-known diseases that begin with the letter M (In alphabetical order):

1. Macular Degeneration: Macular degeneration is an age-related eye disease that leads to the deterioration of the macula, a part of the retina responsible for central vision. It can cause blurred or distorted vision and, in advanced cases, central vision loss. Early diagnosis and appropriate interventions are vital for preserving vision and improving the quality of life for affected individuals.

2. Mad Cow Disease (Bovine spongiform encephalopathy – BSE): Mad Cow Disease, also known as Bovine spongiform encephalopathy (BSE), is a fatal neurological disorder that primarily affects cattle. It can be transmitted to humans through the consumption of infected beef products, leading to variant Creutzfeldt-Jakob Disease (vCJD). Preventive measures, such as strict regulations and testing in the meat industry, are crucial for controlling its spread.

3. Major Depression: Major depression, also known as clinical depression or major depressive disorder (MDD), is a severe mental health condition characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities. It can significantly impact daily life and may require a combination of psychotherapy and medication for effective management.

4. Malaria: Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites. It is prevalent in tropical and subtropical regions and can cause symptoms like fever, chills, and flu-like illness. Early diagnosis and prompt treatment with antimalarial drugs are essential for preventing severe complications and fatalities.

5. Malignant Brain Tumour (cancerous): Malignant brain tumors are cancerous growths that originate in the brain tissue. They can be aggressive and invasive, leading to neurological symptoms like headaches, seizures, and cognitive deficits. Treatment options depend on the tumor type, location, and stage and may include surgery, radiation therapy, and chemotherapy.

6. Mallet Finger: Mallet finger is a common hand injury characterized by the inability to fully extend the finger’s distal joint (DIP joint). It usually occurs due to a tendon injury and is commonly seen in sports-related accidents. Immobilization or splinting of the affected finger is often necessary for proper healing.

7. Malnutrition: Malnutrition refers to a deficiency or imbalance in essential nutrients, leading to adverse effects on health. It can result from inadequate dietary intake, absorption issues, or certain medical conditions. Proper nutrition, dietary supplementation, and medical interventions are essential for treating malnutrition and preventing complications.

8. Mania: Mania is a state of elevated mood and excessive energy often associated with bipolar disorder. It can lead to impulsive behavior, reduced need for sleep, and grandiose thoughts. Managing mania involves mood-stabilizing medications and psychotherapy to achieve mood balance.

9. Maple Syrup Urine Disease (MSUD): Maple Syrup Urine Disease (MSUD) is a rare inherited metabolic disorder that impairs the body’s ability to break down certain amino acids. It leads to the accumulation of toxic substances, causing neurological symptoms and a distinctive sweet-smelling urine odor. Early detection and dietary management are crucial for preventing complications.

10. Marasmus: Marasmus is a severe form of malnutrition that results from insufficient intake of calories, proteins, and other essential nutrients. It commonly affects infants and young children, leading to significant weight loss, muscle wasting, and growth retardation. Timely intervention with proper nutrition and medical care is essential for recovery.

11. Marfan Syndrome: Marfan syndrome is a genetic connective tissue disorder that affects the skeletal system, eyes, and cardiovascular system. It can lead to tall stature, long limbs, and heart valve abnormalities. Regular medical monitoring and appropriate interventions are vital for managing symptoms and preventing complications.

12. Marine Biotoxins Related Diseases: Marine biotoxins are toxins produced by certain algae and can accumulate in shellfish and fish, leading to foodborne illnesses. Diseases related to marine biotoxins include paralytic shellfish poisoning (PSP), amnesic shellfish poisoning (ASP), and ciguatera fish poisoning (CFP). Avoiding the consumption of contaminated seafood is essential for preventing these illnesses.

13. Mastitis: Mastitis is an inflammation of the breast tissue, often occurring during breastfeeding. It can lead to breast pain, redness, and swelling, and in some cases, infection. Proper breastfeeding techniques, frequent emptying of the breasts, and antibiotics (if necessary) are typical treatments for mastitis.

14. Mastocytosis: Mastocytosis is a condition characterized by an excessive number of mast cells, which release histamine and other chemicals in response to triggers. It can lead to skin lesions, gastrointestinal symptoms, and systemic reactions. Management involves avoiding triggers and using medications to control symptoms.

15. Measles: Measles is a highly contagious viral infection characterized by fever, cough, and a distinctive red rash. It can lead to severe complications, especially in young children and individuals with weakened immune systems. Vaccination against measles is the most effective way to prevent its spread.

16. Meconium Aspiration Syndrome: Meconium aspiration syndrome occurs when a newborn inhales meconium (the baby’s first feces) into the lungs during or before delivery. This can lead to respiratory distress and lung inflammation. Treatment involves providing respiratory support and treating any complications.

17. Median Nerve Compression: Median nerve compression, commonly known as carpal tunnel syndrome, occurs when the median nerve in the wrist becomes compressed, leading to numbness, tingling, and weakness in the hand. Rest, wrist splinting, and sometimes surgery are used to alleviate symptoms and prevent further nerve damage.

18. Medication Allergy: Medication allergy refers to an adverse immune reaction to certain medications, leading to allergic symptoms such as rash, itching, and swelling. It is essential to identify the specific medication causing the allergy and avoid its use. Allergy testing can help determine safe alternatives.

19. Medulloblastoma: Medulloblastoma is a malignant brain tumor that primarily affects children. It arises in the cerebellum, the region responsible for motor coordination. Treatment typically involves surgery, radiation, and chemotherapy, and early diagnosis is critical for favorable outcomes.

20. Melanoma: Melanoma is a type of skin cancer that originates in melanocytes, the cells responsible for skin pigmentation. It is often caused by excessive sun exposure and can spread to other parts of the body if not detected early. Treatment involves surgical removal and, in advanced cases, targeted therapies and immunotherapy.

21. Melasma: Melasma is a common skin condition characterized by dark patches on the face, especially in areas exposed to the sun. It is more prevalent in women and can be triggered by hormonal changes. Sun protection and topical treatments are essential for managing melasma.

22. Meniere’s Disease: Meniere’s disease is a disorder of the inner ear that causes episodes of vertigo, hearing loss, tinnitus, and a feeling of fullness in the ear. It can significantly affect balance and quality of life. Treatment includes lifestyle modifications, medication, and sometimes surgery.

23. Meningitis: Meningitis is an inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It can be caused by viruses, bacteria, or fungi and leads to symptoms such as severe headache, fever, and neck stiffness. Prompt medical attention is crucial for diagnosing and treating meningitis.

24. Meningococcal Disease: Meningococcal disease is a bacterial infection caused by Neisseria meningitidis, leading to meningitis or bloodstream infection. It can be life-threatening and requires immediate medical treatment. Vaccination is available to prevent certain types of meningococcal infections.

25. Menopausal Disorders: Menopausal disorders refer to a range of symptoms experienced by women during perimenopause and menopause, including hot flashes, night sweats, and mood changes. Hormone therapy and lifestyle adjustments can help manage these symptoms.

26. Menopause: Menopause marks the end of a woman’s reproductive years and is characterized by the cessation of menstrual periods. Hormonal changes during menopause can lead to various symptoms and health concerns. Managing menopause involves hormone therapy, lifestyle changes, and regular health check-ups.

27. Mental Illness: Mental illnesses encompass a wide range of conditions affecting emotional, cognitive, and behavioral health. Examples include depression, anxiety disorders, schizophrenia, and bipolar disorder. Proper diagnosis, counseling, and medications, if necessary, are crucial for managing mental illnesses.

28. Meralgia Paresthetica: Meralgia paresthetica is a condition that occurs when the lateral femoral cutaneous nerve in the thigh becomes compressed, leading to tingling, burning, and numbness in the outer thigh. It is often caused by tight clothing or weight gain. Rest, avoiding tight clothing, and weight management can help alleviate symptoms.

29. Mesothelioma: Mesothelioma is a rare and aggressive cancer that affects the lining of the lungs, abdomen, or heart. It is primarily caused by exposure to asbestos. Treatment options depend on the disease stage and may include surgery, radiation, and chemotherapy.

30. Metabolic Syndrome: Metabolic syndrome is a cluster of risk factors that increase the risk of heart disease, diabetes, and stroke. These risk factors include obesity, high blood pressure, high blood sugar, and abnormal cholesterol levels. Lifestyle changes, such as healthy eating and regular exercise, are key components of managing metabolic syndrome.

31. Microcephaly: Microcephaly is a congenital condition characterized by an abnormally small head and brain size. It can result in developmental delays and intellectual disabilities. Early intervention and supportive care can help manage the symptoms and improve the child’s quality of life.

32. Middle Ear Infection (Otitis Media): Middle ear infection, or otitis media, is a common childhood illness caused by a bacterial or viral infection in the middle ear. It can lead to ear pain, fluid buildup, and temporary hearing loss. Antibiotics and pain management are often used to treat middle ear infections.

33. Middle East Respiratory Syndrome Coronavirus: Middle East Respiratory Syndrome (MERS) is a viral respiratory illness caused by the MERS coronavirus (MERS-CoV). It is transmitted from animals to humans and, in some cases, between people. Preventive measures and supportive care are essential for managing MERS.

34. Migraine: Migraine is a severe headache disorder characterized by recurrent episodes of intense throbbing pain, often accompanied by nausea and sensitivity to light and sound. Identifying triggers and using medications for pain relief can help manage migraines.

35. Miscarriage: Miscarriage, also known as spontaneous abortion, is the loss of a pregnancy before 20 weeks. It can be emotionally distressing for individuals and families. Medical evaluation and emotional support are essential for those who experience a miscarriage.

36. Mitral Regurgitation: Mitral regurgitation is a heart valve disorder where the mitral valve doesn’t close tightly, allowing blood to flow backward into the left atrium. It can lead to symptoms like fatigue and shortness of breath. Treatment depends on the severity of the condition and may involve medications or surgery.

37. Mitral Stenosis: Mitral stenosis is a heart valve disorder where the mitral valve becomes narrowed, impeding blood flow from the left atrium to the left ventricle. It is often caused by rheumatic fever. Management may include medications or surgical interventions.

38. Mitral Valve Prolapse (MVP): Mitral valve prolapse is a common heart valve condition where the valve flaps don’t close properly, causing a backward flow of blood. In most cases, MVP does not require treatment, but in severe cases, medication or surgery may be necessary.

39. Molluscum Contagiosum: Molluscum contagiosum is a viral skin infection characterized by small, round, painless bumps on the skin’s surface. It is contagious and spreads through direct contact. In many cases, molluscum contagiosum resolves on its own without treatment. However, if necessary, treatments such as cryotherapy or topical medications can be used to remove the bumps.

40. Monkeypox: Monkeypox is a rare viral disease that can cause symptoms similar to smallpox, such as fever, rash, and swollen lymph nodes. It is primarily transmitted to humans from animals, and person-to-person transmission is possible. Isolation, supportive care, and vaccination in high-risk areas are key strategies for controlling monkeypox outbreaks.

41. Mononucleosis (Mono): Mononucleosis, commonly known as “mono,” is a viral infection caused by the Epstein-Barr virus (EBV). It is characterized by flu-like symptoms, fatigue, and a sore throat. Rest, hydration, and over-the-counter pain relievers can help manage mono symptoms.

42. Morbid Obesity: Morbid obesity is a severe form of obesity where excessive body fat poses significant health risks. It can lead to various health complications, including diabetes, heart disease, and joint problems. Lifestyle changes, dietary modifications, and bariatric surgery may be considered for managing morbid obesity.

43. Mosquito-borne Diseases: Mosquito-borne diseases are infections transmitted by mosquitoes, such as malaria, dengue fever, Zika virus, and chikungunya. Prevention measures include mosquito control, using insect repellents, and avoiding mosquito-infested areas.

44. Motion Sickness: Motion sickness is a common condition triggered by movement, such as in cars, boats, or planes. It can cause symptoms like dizziness, nausea, and vomiting. Over-the-counter medications and acupressure bands can help alleviate motion sickness symptoms.

45. Motor Neuron Disease (MND): Motor neuron disease is a group of progressive neurological disorders that affect the nerve cells responsible for muscle movement. Conditions like amyotrophic lateral sclerosis (ALS) fall under this category. There is no cure for MND, but treatments aim to manage symptoms and improve quality of life.

46. Mouth Cancer: Mouth cancer, also known as oral cancer, refers to cancerous growths in the mouth, tongue, lips, or throat. It can be caused by factors like tobacco and alcohol use or human papillomavirus (HPV) infection. Early diagnosis and treatment are crucial for favorable outcomes.

47. Mouth Ulcer: Mouth ulcers are painful sores that can develop inside the mouth, on the lips, or on the tongue. They can be caused by various factors, including stress, injury, or certain medical conditions. Most mouth ulcers heal on their own, but over-the-counter treatments can help with pain relief.

48. Moyamoya Disease: Moyamoya disease is a rare cerebrovascular disorder characterized by the narrowing of blood vessels in the brain, leading to reduced blood flow. It primarily affects children and young adults. Surgical interventions, such as bypass procedures, are often used to restore blood flow and prevent stroke.

49. Mucopolysaccharidosis: Mucopolysaccharidosis (MPS) is a group of inherited metabolic disorders caused by the deficiency of specific enzymes that break down complex carbohydrates. It leads to the accumulation of substances in various organs and tissues, causing a range of symptoms. Management may involve enzyme replacement therapy and supportive care.

50. Mucormycosis: Mucormycosis, also known as black fungus infection, is a rare but serious fungal infection that primarily affects individuals with weakened immune systems. It can affect various body parts, including the sinuses, lungs, and brain. Early diagnosis and antifungal treatment are essential for managing mucormycosis.

51. Multiple Myeloma: Multiple myeloma is a type of cancer that affects plasma cells in the bone marrow, leading to the overproduction of abnormal plasma cells. It can cause bone pain, anemia, and kidney problems. Treatments may include chemotherapy, stem cell transplantation, and targeted therapies.

52. Multiple Sclerosis (MS): Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system, leading to communication problems between the brain and the rest of the body. Symptoms can vary widely and may include fatigue, difficulty walking, and vision problems. Disease-modifying therapies and symptomatic treatments are used to manage MS.

53. Mumps: Mumps is a viral infection that causes swelling of the salivary glands, leading to facial swelling and fever. It is a vaccine-preventable disease, and vaccination is crucial for preventing mumps outbreaks.

54. Muscle Pain: Muscle pain, also known as myalgia, is a common symptom that can result from overuse, injury, or certain medical conditions. Rest, pain relievers, and heat or cold therapy can help alleviate muscle pain.

55. Muscle Spasm: Muscle spasms are involuntary contractions of one or more muscles. They can be caused by dehydration, electrolyte imbalances, or muscle strain. Gentle stretching and hydration are often helpful for relieving muscle spasms.

56. Muscle Strain: A muscle strain occurs when muscle fibers stretch or tear due to overexertion or sudden movements. Rest, ice, compression, and elevation (RICE) are commonly used to treat muscle strains.

57. Muscular Dystrophy: Muscular dystrophy is a group of genetic disorders characterized by progressive muscle weakness and wasting. It is caused by mutations in certain genes responsible for muscle structure and function. There is no cure for muscular dystrophy, but treatments aim to manage symptoms and improve mobility.

58. Myasthenia Gravis: Myasthenia gravis is an autoimmune neuromuscular disorder that causes weakness and fatigue in the muscles, especially those involved in voluntary movements. It is caused by the body’s immune system attacking the neuromuscular junctions. Treatment includes medications that help improve nerve-to-muscle communication.

59. Myasthenic Crisis: Myasthenic crisis is a life-threatening condition that occurs when the muscles responsible for breathing weaken to the point of respiratory failure. It requires immediate medical attention and may require mechanical ventilation.

60. Myelitis: Myelitis refers to inflammation of the spinal cord, which can lead to neurological symptoms such as weakness, sensory changes, and paralysis. It can be caused by infections, immune system disorders, or other factors. Treatment involves managing the underlying cause and providing supportive care.

61. Myelodysplastic Syndrome (MDS): Myelodysplastic syndrome is a group of blood disorders where the bone marrow fails to produce healthy blood cells. It can lead to anemia, infections, and bleeding problems. Treatment options include supportive care, blood transfusions, and stem cell transplantation.

62. Myeloma: Myeloma is a type of cancer that affects plasma cells in the bone marrow, leading to the overproduction of abnormal plasma cells. It can cause bone pain, anemia, and kidney problems. Treatments may include chemotherapy, stem cell transplantation, and targeted therapies.

63. Myocardial Hypertrophy: Myocardial hypertrophy is an enlargement of the heart muscle, often in response to increased workload or certain medical conditions. It can be a normal response to exercise or pathological due to conditions like hypertension or valvular heart disease. Treatment focuses on managing the underlying cause and preventing complications.

64. Myocardial Infarction: Myocardial infarction, commonly known as a heart attack, occurs when blood flow to a part of the heart is blocked, leading to tissue damage. It can cause chest pain, shortness of breath, and other symptoms. Immediate medical attention is critical to restore blood flow and prevent further damage.

65. Myocardial Ischemia: Myocardial ischemia refers to reduced blood flow to the heart muscle, leading to oxygen deprivation. It can be a precursor to a heart attack. Treatment involves improving blood flow and addressing risk factors such as high blood pressure and cholesterol levels.

66. Myocarditis: Myocarditis is inflammation of the heart muscle, often caused by viral infections. It can weaken the heart and lead to heart failure. Treatment may include medications to reduce inflammation and manage heart function.

67. Myopia (Nearsightedness): Myopia, also known as nearsightedness, is a common refractive error where distant objects appear blurry, but close-up objects are clear. It is corrected with eyeglasses, contact lenses, or refractive surgery.

68. Myositis: Myositis is inflammation of the muscles, leading to muscle weakness and pain. It can be caused by autoimmune disorders, infections, or medications. Treatment involves managing the underlying cause and relieving symptoms.

69. Myxedema (Hypothyroidism): Myxedema is a severe form of hypothyroidism, characterized by swelling of the skin and other tissues due to the accumulation of mucopolysaccharides. It can cause fatigue, weight gain, and cold intolerance. Hormone replacement therapy is used to manage hypothyroidism.

70. Narcolepsy: Narcolepsy is a chronic neurological disorder that affects the brain’s ability to regulate sleep-wake cycles. It leads to excessive daytime sleepiness and sudden, uncontrollable episodes of falling asleep. Medications and lifestyle adjustments can help manage narcolepsy symptoms.


I hope you found this article “Diseases That Start With M” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter M.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With N
  • Diseases That Start With O
  • Diseases That Start With P
  • Diseases That Start With Q

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