63 Diseases That Start With The Letter L

Have you ever wondered about diseases that start with the letter “L”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter L, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter L.


Diseases That Start With L

The followings are some known and lesser-known diseases that begin with the letter L (In alphabetical order):

1. Labyrinthitis: Labyrinthitis is an inflammation of the labyrinth, a part of the inner ear responsible for balance and hearing. It can cause vertigo, hearing loss, and nausea. Treatment involves managing symptoms and addressing the underlying cause, often related to viral or bacterial infections.

2. Laceration: A laceration refers to a deep cut or tear in the skin or tissues. It can occur due to accidents, trauma, or medical procedures. Treatment involves cleaning and closing the wound, and in some cases, sutures or staples may be used for proper healing.

3. Lactase Deficiency: Lactase deficiency, also known as lactose intolerance, is the inability to digest lactose, a sugar found in milk and dairy products. It leads to gastrointestinal symptoms like bloating, gas, and diarrhea after consuming lactose-containing foods. Management involves dietary adjustments and lactase enzyme supplements.

4. Lactate Dehydrogenase Deficiency: Lactate dehydrogenase deficiency is a rare genetic disorder that affects the enzyme responsible for converting lactate to pyruvate in the body. It can lead to muscle weakness, fatigue, and other symptoms. Treatment focuses on managing symptoms and supportive care.

5. Lactational Abscess: A lactational abscess is a painful collection of pus in the breast tissue that can occur during breastfeeding. It is usually caused by a bacterial infection. Treatment involves draining the abscess and using antibiotics if necessary.

6. Lactational Mastitis: Lactational mastitis is a breast infection that can occur during breastfeeding. It leads to breast pain, redness, and swelling. Treatment involves rest, warm compresses, and antibiotics if the infection is bacterial.

7. Lactose Intolerance: Lactose intolerance is a common condition where the body cannot digest lactose properly. It leads to gastrointestinal symptoms after consuming dairy products. Management includes avoiding lactose-containing foods or using lactase enzyme supplements.

8. Lactose Malabsorption: Lactose malabsorption refers to reduced absorption of lactose in the small intestine. It can lead to lactose intolerance and gastrointestinal symptoms. Dietary adjustments and lactase enzyme supplements can help manage the condition.

9. Laminectomy: Laminectomy is a surgical procedure to remove part or all of the lamina (the bony arch) of a vertebra to relieve pressure on the spinal cord or nerves. It is often performed to treat spinal stenosis or herniated discs.

10. Landau-Kleffner Syndrome: Landau-Kleffner Syndrome is a rare neurological disorder that affects children and leads to language regression and seizure activity. Treatment involves speech therapy, anti-seizure medications, and other supportive measures.

11. Laryngeal Cancer: Laryngeal cancer is a type of cancer that starts in the larynx (voice box). Common symptoms include hoarseness, difficulty swallowing, and throat pain. Treatment options include surgery, radiation, and chemotherapy.

12. Laryngectomy: Laryngectomy is a surgical procedure to remove the larynx to treat laryngeal cancer or severe injury. It involves creating a permanent hole in the neck (stoma) for breathing and speaking.

13. Laryngitis: Laryngitis is inflammation of the larynx, often caused by viral infections or overuse of the voice. It leads to hoarseness and difficulty speaking. Resting the voice and staying hydrated are essential for recovery.

14. Laryngomalacia: Laryngomalacia is a congenital condition where the soft tissues of the larynx collapse during breathing, causing noisy or difficult breathing in infants. Most cases improve with time, but severe cases may require medical intervention.

15. Laryngopharyngeal Reflux: Laryngopharyngeal reflux (LPR) is a condition where stomach acid flows back into the throat and larynx, leading to symptoms like hoarseness and throat irritation. Treatment involves lifestyle changes and medications to reduce acid reflux.

16. Lassa Fever: Lassa fever is an acute viral illness, primarily reported in West Africa. It is transmitted to humans from infected rodents. Early symptoms include fever, headache, and muscle aches. In severe cases, it can lead to organ failure. Strict infection control measures and supportive care are essential for managing the disease.

17. Latent Tuberculosis: Latent tuberculosis (TB) refers to a condition where a person has TB bacteria in their body but does not have active TB disease. Latent TB is not contagious but can progress to active TB if left untreated. Treatment with antibiotics can prevent the development of active TB.

18. Lateral Epicondylitis (Tennis Elbow): Lateral epicondylitis, commonly known as tennis elbow, is a condition characterized by pain and inflammation in the outer part of the elbow. It is often caused by overuse of the forearm muscles. Rest, physical therapy, and anti-inflammatory medications are typical treatment options.

19. Lateral Meniscus Tear: A lateral meniscus tear is a common knee injury involving damage to the cartilage in the knee joint. It can cause pain, swelling, and limited knee movement. Treatment depends on the severity of the tear and may include rest, physical therapy, or surgical repair.

20. Latex Allergy: Latex allergy is an allergic reaction to proteins found in natural rubber latex. It can cause skin rash, hives, and respiratory symptoms. Avoiding latex products and using latex-free alternatives is essential for preventing allergic reactions.

21. Lead Poisoning: Lead poisoning occurs when lead accumulates in the body, often due to exposure to lead-containing products or contaminated water. It can lead to neurological and developmental problems, particularly in children. Prevention measures include avoiding lead exposure and regular screening.

22. Leg Cramps: Leg cramps are sudden, involuntary muscle contractions in the legs. They can result from dehydration, muscle fatigue, or underlying medical conditions. Stretching and staying hydrated are common self-care measures for relieving leg cramps.

23. Leg Pain: Leg pain can result from various causes, including muscle strain, nerve compression, or circulatory problems. Treatment depends on the underlying cause and may include rest, physical therapy, or medication.

24. Legg-Calve-Perthes Syndrome: Legg-Calve-Perthes Syndrome is a childhood condition where the blood supply to the femoral head (hip bone) is disrupted, leading to bone death and deformation. It can cause hip pain and limping. Treatment aims to preserve the hip joint and may involve bracing or surgery.

25. Legionnaires Disease: Legionnaires disease is a severe form of pneumonia caused by inhaling Legionella bacteria, often found in water sources. It can be life-threatening, particularly in individuals with weakened immune systems or underlying health conditions. Prompt diagnosis and appropriate antibiotic treatment are essential for managing this disease.

26. Leishmaniasis: Leishmaniasis is a parasitic infection transmitted through the bites of infected sandflies. It can manifest as cutaneous, mucocutaneous, or visceral leishmaniasis, affecting the skin, mucous membranes, or internal organs, respectively. Treatment depends on the type of leishmaniasis and may involve antiparasitic medications.

27. Leprosy: Leprosy, also known as Hansen’s disease, is a chronic bacterial infection caused by Mycobacterium leprae. It primarily affects the skin and peripheral nerves, leading to skin lesions and loss of sensation. Multi-drug therapy is highly effective in curing leprosy, and early diagnosis helps prevent complications.

28. Leptin Deficiency: Leptin deficiency is a rare genetic disorder characterized by the absence or reduced production of the hormone leptin, which regulates appetite and metabolism. It leads to severe obesity and metabolic abnormalities. Treatment involves leptin replacement therapy and managing associated health concerns.

29. Leptospirosis: Leptospirosis is a bacterial infection transmitted through the urine of infected animals, usually through contaminated water or soil. It can cause flu-like symptoms, and in severe cases, it can lead to kidney or liver failure. Prompt treatment with antibiotics is vital for recovery.

30. Leukemia: Leukemia is a type of cancer that affects the blood and bone marrow, leading to abnormal white blood cell production. There are various types of leukemia, and treatment depends on the specific subtype and individual factors. It may include chemotherapy, radiation, and stem cell transplantation.

31. Leukocytosis: Leukocytosis refers to an elevated white blood cell count in the blood. It can be a sign of infection, inflammation, or other medical conditions. Identifying and treating the underlying cause is crucial for managing leukocytosis.

32. Lice Infestation (Pediculosis): Lice infestation, also known as pediculosis, occurs when parasitic lice infest the scalp, body, or pubic hair. It can cause itching and discomfort. Treatment involves using medicated shampoos or lotions to eliminate lice and their eggs.

33. Lichen Planus: Lichen planus is a chronic inflammatory condition that affects the skin, mucous membranes, hair, and nails. It leads to itchy, flat-topped, purple-colored bumps on the skin. Treatment aims to relieve symptoms and may include topical or oral medications.

34. Lichen Sclerosus: Lichen sclerosus is a skin condition that primarily affects the genital and anal areas. It can cause itching, pain, and changes in the appearance of the skin. Treatment involves using topical corticosteroids to manage symptoms.

35. Lichen Simplex Chronicus: Lichen simplex chronicus is a skin disorder characterized by thickened, leathery skin due to chronic scratching or rubbing. It often results from persistent itching caused by an underlying condition. Treatment focuses on breaking the itch-scratch cycle and managing the underlying cause.

36. Lightheadedness: Lightheadedness is a sensation of feeling faint, dizzy, or weak. It can result from various factors, such as low blood pressure, dehydration, or anxiety. Identifying the underlying cause is essential for appropriate management.

37. Lipid Metabolism Disorder: Lipid metabolism disorders are a group of genetic conditions that affect the processing of fats (lipids) in the body. Examples include familial hypercholesterolemia and familial hypertriglyceridemia. Treatment involves lifestyle modifications, medications, and managing associated health risks.

38. Lipoid Proteinosis: Lipoid proteinosis is a rare genetic disorder that affects the skin, mucous membranes, and other organs. It can lead to hoarse voice, skin thickening, and neurological symptoms. There is no cure, but treatment focuses on managing symptoms and complications.

39. Lipoma: A lipoma is a benign growth of fat cells under the skin. It appears as a soft, movable lump and is usually painless. Surgical removal may be considered for cosmetic or symptomatic reasons.

40. Liposarcoma: Liposarcoma is a rare type of soft tissue sarcoma that originates in fat cells. It can occur in various parts of the body. Treatment involves surgery, radiation, and sometimes chemotherapy, depending on the tumor’s size and location.

41. Listeria Infection: Listeria infection is a foodborne illness caused by consuming contaminated foods, especially unpasteurized dairy products, deli meats, and certain vegetables. It can cause flu-like symptoms, particularly in vulnerable populations like pregnant women and those with weakened immune systems.

42. Listeriosis: Listeriosis is a serious infection caused by the bacterium Listeria monocytogenes. It primarily affects pregnant women, newborns, the elderly, and individuals with weakened immune systems. The infection can lead to severe symptoms and complications, and early treatment with antibiotics is crucial.

43. Lithiasis (Renal Stones): Lithiasis refers to the formation of stones (calculi) in the urinary tract, most commonly in the kidneys (renal stones). Treatment depends on the size and location of the stones and may involve medications or procedures to remove or break down the stones.

44. Liver Cancer: Liver cancer, also known as hepatocellular carcinoma, is a type of cancer that originates in the liver. It is often associated with chronic liver diseases like cirrhosis and hepatitis B or C infections. Treatment options include surgery, ablation therapy, transplantation, and targeted therapies.

45. Liver Cirrhosis: Liver cirrhosis is a late-stage liver disease characterized by scarring of the liver tissue. It is often a result of chronic liver damage and can lead to liver failure. Treatment focuses on managing complications and addressing the underlying cause.

46. Liver Disease: Liver disease encompasses a range of conditions affecting the liver, such as hepatitis, fatty liver disease, and liver cirrhosis. Treatment varies depending on the specific disease and may involve lifestyle changes, medications, or other interventions.

47. Liver Tumors: Liver tumors can be benign or malignant and may originate in the liver (primary liver tumors) or spread from other organs (metastatic liver tumors). Treatment options depend on the type and stage of the tumor and may include surgery, ablation therapy, or chemotherapy.

48. Lobar Pneumonia: Lobar pneumonia is a type of pneumonia that affects one or more lobes of the lung. It is usually caused by bacterial infections, and treatment involves antibiotics and supportive care.

49. Loeffler Endocarditis: Loeffler endocarditis is a rare condition characterized by inflammation of the heart’s endocardium (lining) due to eosinophilic infiltration. It is often associated with parasitic infections or certain allergic reactions. Treatment involves managing the underlying cause and addressing cardiac complications if necessary.

50. Löffler Syndrome: Löffler Syndrome is a rare condition characterized by transient lung infiltrates and eosinophilia (increased eosinophil levels in the blood). It can be caused by parasitic infections or other allergic reactions. Treatment involves addressing the underlying cause and managing respiratory symptoms.

51. Long QT Syndrome: Long QT syndrome is a cardiac disorder that affects the heart’s electrical activity, leading to irregular heartbeats (arrhythmias). It can cause fainting, seizures, and sudden cardiac arrest. Treatment may involve medications, lifestyle modifications, or implanted devices to regulate heart rhythm.

52. Loss of Libido: Loss of libido refers to a decrease in sexual desire or interest. It can be caused by various factors, including stress, hormonal imbalances, or relationship issues. Identifying the underlying cause and addressing any emotional or medical factors is essential for managing this concern.

53. Lou Gehrig’s Disease (ALS): Lou Gehrig’s Disease, also known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative disorder that affects motor neurons, leading to muscle weakness and paralysis. There is no cure for ALS, and treatment focuses on managing symptoms and improving quality of life.

54. Louse-borne Diseases: Louse-borne diseases are infectious illnesses transmitted by lice, such as typhus and relapsing fever. Preventive measures include maintaining personal hygiene, avoiding close contact with infested individuals, and treating infestations promptly.

55. Low Back Pain: Low back pain is a common condition affecting the lower part of the spine. It can be caused by muscle strain, spinal disc problems, or other factors. Treatment may involve rest, physical therapy, pain medications, or in some cases, surgery.

56. Lumbar Spondylosis: Lumbar spondylosis is a degenerative condition affecting the lower spine, leading to wear and tear of the vertebral discs and facet joints. Treatment involves pain management, physical therapy, and lifestyle modifications.

57. Lung Abscess: A lung abscess is a localized collection of pus in the lung tissue. It can result from bacterial infections, aspiration, or other factors. Treatment includes antibiotics, drainage of the abscess, and supportive care.

58. Lung Cancer: Lung cancer is a malignant tumor that originates in the lungs. It is one of the most common cancers worldwide and is often associated with smoking. Treatment options depend on the type and stage of lung cancer and may include surgery, radiation, chemotherapy, or targeted therapies.

59. Lupus: Lupus, or systemic lupus erythematosus (SLE), is an autoimmune disease that can affect various organs and tissues in the body. It leads to inflammation, joint pain, skin rashes, and fatigue. Treatment involves medications to manage inflammation and suppress the immune response.

60. Lyme Disease: Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi. It can lead to flu-like symptoms, joint pain, and a characteristic skin rash called erythema migrans. Early detection and treatment with antibiotics are crucial for preventing complications.

61. Lymphedema: Lymphedema is a condition characterized by swelling, usually in the arms or legs, due to a buildup of lymph fluid. It can result from damage to the lymphatic system, often caused by cancer treatment or infections. Treatment involves compression therapy, exercise, and skin care.

62. Lymphogranuloma Venereum (LGV): Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by certain strains of Chlamydia trachomatis. It primarily affects the lymph nodes in the genital and anal regions. Early detection and treatment with antibiotics are essential for preventing complications.

63. Lymphoma: Lymphoma is a type of cancer that originates in the lymphatic system, a part of the immune system. It includes various subtypes, such as Hodgkin lymphoma and non-Hodgkin lymphoma. Treatment depends on the specific type and stage of lymphoma and may include chemotherapy, radiation, or targeted therapies.


I hope you found this article “Diseases That Start With L” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter L.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With M
  • Diseases That Start With N
  • Diseases That Start With O
  • Diseases That Start With P

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