54 Diseases That Start With The Letter K

Have you ever wondered about diseases that start with the letter “K”? Wonder no more, this article is exactly what you are looking for.

In this article, I will dive into the realm of some known and lesser-known diseases beginning with this enigmatic letter K, aiming to raise awareness and understanding.

So, without any further ado, let’s embark on this fascinating journey and broaden our understanding of diseases that start with the letter K.


Diseases That Start With K

The followings are some known and lesser-known diseases that begin with the letter K (In alphabetical order):

1. Kala-azar (Visceral Leishmaniasis): Kala-azar, also known as Visceral Leishmaniasis, is a severe parasitic infection caused by the Leishmania parasite. It affects the internal organs, including the spleen, liver, and bone marrow. Kala-azar is transmitted through the bites of infected sandflies and can be life-threatening if left untreated. Symptoms include fever, weight loss, and enlarged organs. Timely diagnosis and appropriate treatment with antiparasitic drugs are crucial for managing the disease.

2. Kandinsky-Clerambault Syndrome: Kandinsky-Clerambault Syndrome, also known as the Syndrome of Reduplicative Paramnesia, is a rare neurological disorder characterized by delusional beliefs that a place or location has been duplicated or relocated. It is associated with brain injuries or lesions in specific regions. Treatment involves managing the underlying cause and addressing the psychiatric symptoms through counseling and medication.

3. Kaposi’s Sarcoma: Kaposi’s Sarcoma is a rare form of cancer that develops from the cells lining blood vessels or lymph nodes. It is often associated with infections caused by the human herpesvirus 8 (HHV-8). Kaposi’s Sarcoma can appear as skin lesions or affect the internal organs. Treatments vary depending on the extent and location of the tumors and may include surgery, radiation, and chemotherapy.

4. Kartagener Syndrome: Kartagener Syndrome, also known as Primary Ciliary Dyskinesia (PCD), is a rare genetic disorder affecting the cilia—tiny hair-like structures that line the respiratory tract and other organs. Individuals with Kartagener Syndrome may experience chronic respiratory infections, infertility, and situs inversus (organs on the opposite side of the body). Management focuses on respiratory support and treating associated complications.

5. Kartagener’s Syndrome: Kartagener’s Syndrome is another term for Kartagener Syndrome, as mentioned above. It is a rare genetic disorder affecting ciliary function and leading to various health issues.

6. Kasabach-Merritt Syndrome: Kasabach-Merritt Syndrome is a rare medical condition characterized by the development of a large vascular tumor and severe thrombocytopenia (low platelet count). The tumor can lead to bleeding and other complications. Treatment involves addressing the tumor and managing the associated bleeding and low platelet levels.

7. Kashin-Beck Disease: Kashin-Beck Disease is a chronic and degenerative joint disorder that primarily affects children and adolescents in certain regions. It is associated with malnutrition and selenium deficiency. The disease can lead to joint deformities and impaired mobility. Prevention and treatment involve dietary interventions and selenium supplementation.

8. Kawasaki Disease: Kawasaki Disease is an acute febrile illness that mainly affects young children. It causes inflammation in the blood vessels throughout the body, leading to various symptoms like fever, rash, swollen lymph nodes, and red eyes. Prompt diagnosis and treatment with intravenous immunoglobulin are vital to prevent complications, particularly coronary artery aneurysms.

9. Kearns-Sayre Syndrome: Kearns-Sayre Syndrome is a rare mitochondrial disorder that affects multiple systems, including the eyes, muscles, and heart. It can cause progressive external ophthalmoplegia (eye muscle weakness) and cardiac conduction defects. There is currently no cure, and treatment is supportive.

10. Kegel Exercise (Used for certain medical conditions): Kegel exercises are pelvic floor exercises used to strengthen the muscles responsible for bladder control. They are often recommended to treat urinary incontinence, pelvic organ prolapse, and certain other medical conditions affecting the pelvic region.

11. Keipert Syndrome: Keipert Syndrome is a rare neurological disorder characterized by intellectual disability, epilepsy, and movement abnormalities. The exact cause of the condition is not well understood, and treatment focuses on symptom management and supportive care.

12. Keloids: Keloids are raised overgrowths of scar tissue that can develop after an injury or surgery. They can be itchy, painful, and aesthetically displeasing. Treatment options include corticosteroid injections, silicone gel sheets, and surgical removal, though keloids may recur after treatment.

13. Keratitis: Keratitis is an inflammation of the cornea, the transparent outer layer of the eye. It can be caused by infections, injuries, or underlying medical conditions. Timely treatment is essential to prevent complications that could lead to vision loss.

14. Keratoacanthoma: Keratoacanthoma is a benign skin tumor that resembles squamous cell carcinoma. It typically grows rapidly and may spontaneously regress over time. Treatment involves surgical removal or other therapeutic methods, depending on the tumor’s size and location.

15. Keratoconjunctivitis Sicca (Dry Eye): Keratoconjunctivitis Sicca, commonly known as Dry Eye Syndrome, is a condition where the eyes do not produce enough tears or the tears evaporate too quickly. This leads to eye discomfort, redness, and blurry vision. Management includes artificial tear drops, lifestyle changes, and addressing the underlying cause.

16. Keratoconus: Keratoconus is a progressive eye disorder that causes the cornea to thin and bulge, leading to distorted vision. It often starts during adolescence or early adulthood. Treatment options include eyeglasses, contact lenses, and in severe cases, corneal transplant surgery.

17. Keratoderma: Keratoderma refers to various skin conditions where the skin on the palms and soles becomes thickened and hyperkeratotic. It can be inherited or acquired and may require different treatment approaches based on the underlying cause.

18. Keratosis: Keratosis is a general term for skin growths that result from the overproduction of keratin, a protein in the skin. The types of keratosis include actinic keratosis (sun-related), seborrheic keratosis (non-cancerous), and others. Treatment may involve cryotherapy, topical medications, or surgical removal.

19. Keratosis Pilaris: Keratosis Pilaris is a common skin condition characterized by small, rough bumps on the skin’s surface, particularly on the upper arms and thighs. It is harmless but can be bothersome. Moisturizers and gentle exfoliation are often used to manage the condition.

20. Keutel Syndrome: Keutel Syndrome is an extremely rare genetic disorder characterized by abnormal cartilage calcification, hearing loss, and other features. Treatment primarily involves symptom management and supportive care.

21. KID Syndrome (Keratitis, Ichthyosis, Deafness Syndrome): KID Syndrome is a rare genetic disorder characterized by skin abnormalities (ichthyosis), eye inflammation (keratitis), and hearing loss (deafness). It is caused by mutations in the GJB2 gene. Management includes treating skin symptoms, addressing eye inflammation, and providing support for hearing loss.

22. Kidney Cancer: Kidney Cancer, also known as renal cell carcinoma, is a type of cancer that originates in the kidneys. Common symptoms include blood in the urine, pain in the side or lower back, and weight loss. Treatment options depend on the stage and type of kidney cancer and may include surgery, radiation, and targeted therapies.

23. Kidney Cyst: Kidney Cysts are fluid-filled sacs that can develop in the kidneys. Most kidney cysts are benign and do not require treatment unless they cause pain or other complications. In some cases, large or symptomatic cysts may be drained or surgically removed.

24. Kidney Failure: Kidney Failure, also known as End-Stage Renal Disease (ESRD), occurs when the kidneys lose their ability to filter waste products and maintain fluid and electrolyte balance. It can result from various underlying conditions, such as diabetes or hypertension. Treatment options include dialysis or kidney transplantation.

25. Kidney Infection: A Kidney Infection, also called pyelonephritis, is a severe type of urinary tract infection that affects one or both kidneys. Symptoms include fever, back pain, and frequent urination. Prompt treatment with antibiotics is essential to prevent complications and kidney damage.

26. Kidney Stones: Kidney Stones are hard mineral and salt deposits that form in the kidneys. They can cause severe pain when passing through the urinary tract. Treatment may involve pain management, hydration, and in some cases, medical procedures to remove or break down the stones.

27. Kienböck’s Disease: Kienböck’s Disease is a condition where the blood supply to one of the small bones in the wrist (lunate bone) is disrupted, leading to its gradual deterioration. It can cause wrist pain, stiffness, and limited wrist movement. Treatment options range from conservative measures to surgical interventions, depending on the disease’s stage and severity.

28. Kikuchi Disease: Kikuchi Disease, also known as histiocytic necrotizing lymphadenitis, is a rare, benign condition characterized by enlarged lymph nodes and fever. Most cases resolve on their own, and treatment focuses on managing symptoms and monitoring the condition.

29. Kikuchi-Fujimoto Disease: Kikuchi-Fujimoto Disease is another term for Kikuchi Disease, as mentioned above. It is a rare condition that primarily affects the lymph nodes.

30. Kimmelstiel-Wilson Disease (Diabetic Nephropathy): Kimmelstiel-Wilson Disease, also known as Diabetic Nephropathy, is a complication of long-term diabetes that affects the kidneys. It leads to progressive kidney damage and can result in kidney failure. Early detection and tight control of blood sugar levels are crucial for preventing or slowing the progression of the disease.

31. Kimmelstiel-Wilson Syndrome: Kimmelstiel-Wilson Syndrome is another term for Kimmelstiel-Wilson Disease, as mentioned above. It refers to the kidney changes associated with diabetic nephropathy.

32. Klatskin Tumor: A Klatskin Tumor is a type of cholangiocarcinoma, a cancer that starts in the bile ducts of the liver. It can cause obstruction of the bile ducts, leading to jaundice and other symptoms. Treatment options include surgery, radiation, and chemotherapy.

33. Kleine-Levin Syndrome: Kleine-Levin Syndrome, also known as “Sleeping Beauty” syndrome, is a rare neurological disorder characterized by recurrent episodes of excessive sleep, altered behavior, and hyperphagia (increased food intake). The cause is not fully understood, and treatment focuses on managing symptoms during episodes.

34. Klinefelter Syndrome: Klinefelter Syndrome is a genetic disorder in males caused by an extra X chromosome (XXY instead of XY). It leads to hormonal imbalances and can cause infertility and other physical and developmental differences. Treatment may include hormone therapy and fertility options.

35. Klippel-Trenaunay Syndrome: Klippel-Trenaunay Syndrome is a rare congenital condition characterized by vascular malformations, limb overgrowth, and port-wine stains (birthmarks). Management involves addressing specific symptoms and providing support to individuals with the syndrome.

36. Klippel-Trenaunay-Weber Syndrome: Klippel-Trenaunay-Weber Syndrome is a rare condition similar to Klippel-Trenaunay Syndrome, but it also involves capillary malformations and soft tissue and bone hypertrophy. Treatment focuses on managing complications and providing supportive care.

37. Kluver-Bucy Syndrome: Kluver-Bucy Syndrome is a rare neurological disorder caused by damage to the temporal lobes of the brain. It can lead to behavioral changes, hypersexuality, and reduced fear responses. Treatment is primarily supportive and focused on addressing specific symptoms.

38. Knee Osteoarthritis: Knee Osteoarthritis is a degenerative joint disease that occurs when the cartilage in the knee joint wears away, leading to pain, stiffness, and reduced mobility. Treatment options include pain management, physical therapy, and in severe cases, knee replacement surgery.

39. Knee Pain: Knee Pain can result from various causes, including injuries, overuse, and medical conditions like arthritis. Treatment depends on the underlying cause and may involve rest, physical therapy, and medication.

40. Kniest Dysplasia: Kniest Dysplasia is a rare genetic disorder that affects cartilage and bone development, leading to short stature, skeletal abnormalities, and vision and hearing impairments. Treatment focuses on managing symptoms and providing support for affected individuals.

41. Kocher-Debre-Semelaigne Syndrome: Kocher-Debre-Semelaigne Syndrome, also known as Hypothyroid Muscular Pseudohypertrophy, is a rare condition characterized by muscle weakness and hypertrophy (enlargement) due to hypothyroidism. Treatment involves thyroid hormone replacement therapy.

42. Koilonychia: Koilonychia is a condition where the nails become concave and spoon-shaped. It can be a symptom of certain medical conditions, such as iron deficiency anemia. Treatment involves addressing the underlying cause and ensuring adequate nutrition.

43. Korsakoff Syndrome: Korsakoff Syndrome is a neurological disorder primarily caused by severe thiamine (vitamin B1) deficiency, often resulting from chronic alcohol abuse. It leads to memory problems, confabulation (fabricating false memories), and difficulties with learning. Treatment involves thiamine supplementation and support to manage cognitive deficits.

44. Korsakoff’s Psychosis: Korsakoff’s Psychosis is another term for Korsakoff Syndrome, as mentioned above. It refers to the cognitive and memory impairments associated with thiamine deficiency.

45. Korsakov’s Syndrome: Korsakov’s Syndrome is another term for Korsakoff Syndrome, as mentioned above. It is named after the Russian neuropsychiatrist Sergey Korsakov, who first described the condition.

46. Krukenberg Tumor: A Krukenberg Tumor is a rare type of ovarian cancer that spreads from other organs, most commonly the stomach. It is characterized by the presence of signet ring cells. Treatment involves surgery and chemotherapy.

47. Kuru (Prion Disease): Kuru is a rare and fatal neurodegenerative disease caused by prion proteins. It was once prevalent among the Fore people of Papua New Guinea, who practiced cannibalism. The disease is now rare due to changes in cultural practices. There is no cure for kuru, and treatment is supportive.

48. Kuskokwim Disease: Kuskokwim Disease is a rare genetic disorder affecting the muscles, bones, and connective tissues. It is primarily found in the Yupik Eskimo people of southwestern Alaska. The condition can lead to joint deformities and movement difficulties. Treatment focuses on managing symptoms and providing supportive care.

49. Kussmaul Breathing: Kussmaul Breathing is a specific type of deep, rapid, and labored breathing often observed in individuals with metabolic acidosis (a condition where the body accumulates excessive acid). It is the body’s attempt to compensate for the acidosis by increasing the elimination of carbon dioxide through respiration.

50. Kuzniecowa-Christoffel Syndrome: Kuzniecowa-Christoffel Syndrome is an extremely rare genetic disorder characterized by intellectual disability, seizures, and developmental delays. There is limited information about the syndrome, and treatment focuses on managing symptoms and providing supportive care.

51. Kyasanur Forest Disease: Kyasanur Forest Disease is a tick-borne viral infection transmitted to humans from infected animals, particularly monkeys and rodents. It is prevalent in certain regions of India. The disease can cause fever, headache, and bleeding tendencies. Prevention measures include tick avoidance and vaccination.

52. Kyphoplasty: Kyphoplasty is a surgical procedure used to treat spinal compression fractures, often caused by osteoporosis. It involves inflating a balloon in the fractured vertebra and then injecting bone cement to stabilize the bone and relieve pain.

53. Kyphoscoliosis: Kyphoscoliosis is a condition where the spine has both abnormal lateral (sideways) curvature (scoliosis) and abnormal front-to-back curvature (kyphosis). It can lead to a range of symptoms and may require bracing or surgery, depending on the severity.

54. Kyphosis: Kyphosis is a spinal deformity characterized by an excessive forward curvature of the upper back. It can result from various factors, including poor posture, spinal degeneration, or developmental conditions. Treatment options include physical therapy, bracing, and in severe cases, surgery.


I hope you found this article “Diseases That Start With K” helpful and got insights into some of the rare and lesser-known medical conditions.

Also, keep in mind that, this isn’t an exhaustive list, if there are any Diseases starting with the letter K.

Feel free to leave a comment below with the missing Disease and I’ll update the list as soon as possible.

And, if you’d like to explore more Diseases starting with different letters of the alphabet, click the link below:

  • Diseases That Start With L
  • Diseases That Start With M
  • Diseases That Start With N
  • Diseases That Start With O

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